Tissue K+ and Na+ distribution in renal interstitial disease assessed by 39K and 23Na MRI (C07*)

在这个项目中，我们将描述肾小管功能障碍的组织电解质分布。因此，我们将开发新的磁共振成像方法来分析组织离子浓度。具体地说，23Na和39K磁共振将用于检测醛固酮增多症的肌肉Na+和K+移位。此外，我们将利用人体肾脏的形态成像和23Na成像来确定生理上的Na+变化。由于组织中的Na+滞留发生在炎症中，我们假设急性同种异体移植排斥反应的特征是组织中的Na+积聚，并可通过23NaMRI检测到。此外，我们还将评估SGLT-2抑制剂如何影响慢性肾脏病和心力衰竭患者的肾脏Na+和肾外Na+&K+浓度。

In this project we will characterize the tissue electrolyte distribution in renal tubular dysfunction. We will therefore develop new MRI methodology to analyse tissue ion concentrations. Specifically, 23Na & 39K MRI will be applied to detect muscle Na+ & K+ shifts in aldosteronism. Furthermore, we will utilize combined morphological and 23Na imaging of the human kidneys to determine physiological Na+ variations. As tissue Na+ retention occurs in inflammation, we hypothesize that acute allograft rejection is characterized by tissue Na+ accumulation and can be detected by 23Na MRI. Besides, we will evaluate how SGLT-2 inhibitors influence the kidney Na+ and extrarenal Na+ & K+ concentrations in CKD and heart failure.