Control and physiology of totally replaced turbo artificial heart

在体外研究中，我们使用一种特别设计的模拟电路作为CFAH，该电路由一个囊型脉动泵、三个储液器和我们的混流泵(MFP)组成。监测电机电流波形。将MFP的泵速从2000转/分改变为5000转/分，用电机电流幅值除以同步平均值计算出电机电流幅值指数(ICA)。根据泵速(ICA-泵速关系)绘制的ICA图显示了几个特征点：t-i点、Pr0.7点、Pr0.5点和MaxQ点。从部分左心辅助到完全左心辅助，t-i点与调谐点强烈对应。当收缩系数、后负荷和预负荷改变时，各点的泵流量都会发生变化，这取决于预负荷的变化，就像斯塔林定律一样。这些…更多的数据表明，通过检测ICA-泵速度关系的特征点，研究连续流量泵控制双心室辅助装置的方法，可以判断CFAH的辅助状态。夹闭升主动脉根部造成大鼠全脑缺血30min。开放主动脉后，每隔1小时评估一次泵性能分析，再灌流6小时以上。为了在没有任何特定传感器的情况下检测心室收缩，我们计算了根据电机电流波形和同步平均电流值的电流幅度指数(ICA)，并将这些数据应用于控制BVAD。通过设置目标LVAD流量和目标ICA值来确定RVAD速度。使用LVAD目标ICA值，我们可以设置与心功能匹配的RVAD流速。利用已知的泵流量或泵流量估计值可以作为连续流泵控制BVAD的一种方法。较少

Detection and implications of the characteristic points for estimating the assisting condition in a continuous-flow artificial heart -In vitro study-In this study, we used a specially devised mock circuit consisting of a sac-type pulsatile pump, three reservoirs, and our mixed flow pump (MFP) as a CFAH. The motor current waveform was monitored. The pump speed of the MFP was changed from 2000 rpm to 5000 rpm, We calculated the index of motor current amplitude (ICA), which was obtained, by dividing the amplitude of the motor current by the simultaneous mean value. The ICA plotted against the pump speed (ICA-pump speed relationship) showed several characteristic points: the t-i point, the PR0.7 point, the PR0.5 point, and the maxQ point. The t-i points strongly corresponded to the tuning point from partial to total left heart assistance. When the contractility, afterload, and preload were changed, the pump flow rate at each point changed, depending on the preload like Starling's law. Thes … More e data suggest that the assisting status of a CFAH could be estimated by detecting the characteristic points of the ICA-pump speed relationship,Investigation of the methods of controlling the Biventricular Assist Device with continuous flow pumps.Using 5 piglets, we set a BVAD with continuous flow pumps via left thoracotomy. Global ischemia was induced for 30 minutes by clamping the base of the ascending aorta. After unclamping the aorta, the analysis of pumping performance was evaluated every an hour for over 6 hours reperfusion. To detect ventricular collapse without any specific sensor, we calculated the index of current amplitude (ICA) from motor current waveforms and simultaneous mean current values, and applied these data when controlling the BVAD. The RVAD speed was determined by setting the target LVAD flow and target ICA value. Using the LVAD target ICA value, we could set the RVAD flow rate to match cardiac function. Using the known pump flow or the pump-flow estimation can be one method of controlling BVAD with continuous flow pumps. Less