Development of next generation ventricular assist system and study of long-term assisted circulation

下一代心室辅助系统开发及长期辅助循环研究

• 批准号: 03404041
• 负责人: TAKANO Hisateru
• 金额: $ 15.62万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03404041/
• 关键词: Left ventricular assist system; Abdominally placed blood pump; Impedance; portable control drive unit; インピーダンス法; 制御駆動装置; 簡易駆動装置; 心尖脱血; 電気インピーダンス法; 腹壁内埋め込み型血液ポンプ; 電気インピ-ダンス

We have developed an implantable left ventricular assist system (LVAS) for small sized adult patients. The pump made of segmented polyether poly-urethane was pneumatic driven diaphragm type, which was designed to be positioned in the left abdominal wall. Nine of them were sacrificed after 4 to 18 weeks in good physical condition. The electrical impedance-based monitoring and control system (Z system) was developed for adequate monitoring and automatic control. The performance of the implanted pump was well monitored and the full-fill to full-empty drive was well controlled by the Z system. In conclusion, this LVAS is promising for clinical use.

我们已经开发了一种植入式左心室辅助系统（LVAS）的小型成人患者。泵由多段聚醚聚氨酯制成，为气动隔膜式，设计定位于左腹壁。其中9只在4 ~ 18周后在身体状况良好的情况下被处死。为了实现充分的监测和自动控制，开发了基于电阻抗的监测和控制系统（Z系统）。植入泵的性能得到了很好的监测，Z系统很好地控制了满充至满空驱动。总之，该LVAS具有临床应用前景。

项目成果

ANAI H.,Takano H.,et al: "CONTINUOUS MONITORING SYSTEM.OF PUMP PERFORMANCE AND ITS APPLICATION FOR ARTIFICIAL HEART PRIVING" ASAIO Transactions.

ANAI H.、Takano H. 等人：“泵性能连续监测系统及其在人工心脏手术中的应用”ASAIO 交易。

Nakatani T,et al.: "An abdominally placed, implantable left ventricular assist system for longterm use" Trans Am Soc Artif Intern Organs. 38. M631-M633 (1992)

Nakatani T 等人：“一种可长期使用的腹部植入式左心室辅助系统”Trans Am Soc Artif Intern Organs。

Nakatani T.et al.: "An implantable left ventricular assist systm with an electrical impalance monitory and control system." ASAIO Journal. 39. M644-M648 (1993)

Nakatani T.et al.：“一种带有电平衡监测和控制系统的植入式左心室辅助系统。”

Nakatani T.et al.: "Development of an implantable left ventricular assist system for bridge to heart transplant" Jpn J Artif Organs. 23 (3). 637-640 (1994)

Nakatani T.et al.：“开发用于心脏移植桥梁的植入式左心室辅助系统”Jpn J Artif Organs。

中谷武嗣 他: "重症心不全に対する補助循環法としての補助人工心臓とCardiomyoplastyについて" 人工臓器. 22. 300-305 (1993)

Taketsugu Nakatani 等人：“关于辅助人工心脏和心肌成形术作为严重心力衰竭的辅助循环方法”Artificial Organs。