Bone morphometric imeging using morphological filter.

利用第三腰椎的18个松质骨块研究评估椎体骨强度的结构参数，以评估骨质疏松症的药物治疗效果。将每个骨块的骨小梁模式二值化为骨小梁模式，并通过星体积分析将其量化为骨小梁像素百分比（SKP）和骨小梁星形体积（Vt）。然后通过双x线吸收仪和力学试验测定各骨块的骨密度（BMD）和弹性，以确定SKP与vt的相关性。在本研究中，骨密度与弹性之间没有显著相关性。尽管骨密度基本相同，但不同骨块之间的弹性差异很大。由垂直和水平连续线条组成的网格状骨骼图案具有较高的弹性。SKP与弹性的相关性高于BMD，但波动范围较窄。Vt与弹性的相关性高于SKP，而SKP- bmd和Vt- bmd的相关性较弱。这些结果表明，形态学滤波的星形体积分析得到的SKP和Vt作为分析腰椎药物治疗效果的结构参数比BMD更有效。

Structuring parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra to evaluate the therapeutic efficiency of medication on osteoporosis.The trabecular bone pattern of each bone block was binarized into a trabecular skeletal pattern and they were quantified into a trabecular skeletal pixel percentage (SKP) and trabecular skeletal star volume (Vt) by star volume analysis. Then the bone mineral density (BMD) and elasticity of each bone block were measured by dual x-ray absorptiometry and mechanical tests to determine the correlations between SKP and Vt.In the present study, no significant correlations were observed between BMD and elasticity. Elasticity differed greatly between some bone blocks even though BMD was essentially the same. Grid-like skeletal patterns consisting of vertical and horizontal continuous lines showed higher elasticity. SKP showed higher correlations with elasticity than BMD, although the fluctuation range was narrow. Meanwhile, Vt showed higher correlations with elasticity than SKP, and the SKP-BMD and Vt-BMD correlations were weak.These results indicate that SKP and Vt obtained by star volume analysis using a morphological filter are more effective than BMD as structural parameters for analyzing the therapeutic efficiency of medication on lumbar vertebra.