Multi-sensors system of physiological signals detected in oral cavity for health care monitoring

对生理信息进行无创、连续、无约束的监测，是检查人体健康状况和管理应激的必要手段，是预防老年人和青年人在日常生活中患病或猝死的必要手段。我们研制了一种新型的口套式传感器系统，该系统紧密固定在口腔内，可同时监测体温、动脉脉搏波和唾液。光体积脉搏波检测采用led和光电二极管，口腔温度测量采用热敏电阻器桥电路。氧化铱和Ag/AgGl电极也用于唾液pH检测。这些传感器被嵌入由牙科树脂制成的牙套（义齿基托）中。这些信号由PFM-FM无线遥测系统传输，由PC机处理系统采集，可以在工作、睡眠甚至运动时使用。透光率可能在周长15分钟左右。利用监测系统，主要通过时间序列分析和频谱分析，评估静息和轻度精神负荷下与精神应激和累积疲劳相关的心率变异性、呼吸变异性、体温和唾液分泌等自主功能指标。将这些指标与主观问卷进行比较，从中可以很好地提取精神疲劳状态。所研制的多传感器系统对人体各种身体状况的连续监测和健康护理具有良好的可用性和有效性。

Noninvasive, continuous and unrestraint monitoring of physiological informations is necessary for checking human health condition and stress management to prevent illness or sudden death of the aged and young persons on their daily life. We developed a novel sensor system of mouthpiece type which was tightly fixed in the oral cavity and available to simultaneous monitoring of body temperature, arterial pulse wave and salivary pH.LED and photodiode were used for photoplethysmographic arterial wave detection while a thermistor bridge circuit was used for oral temperature measurement. Iridium oxide and Ag/AgGl electrodes were also used for salivary pH detection. These sensors were embedded in the mouthpiece (denture base) which was made of dental resin. These signals were transmitted by PFM-FM wireless telemeter system and were acquisited in a PC processing system, which can be used while at work, sleeping and even at exercise. Possibility of the transmittance was about 15 min circumference.By using the monitoring system, mainly, autonomic function indicators of heart rate variability, respiratory variability, body temperature and salivary secretion related with mental stress and cumulative fatigue were assessed by means of time series analysis as well as spectral analysis under resting and light mental workload. These indicators were compared with subjective questionnaires from which the mental fatigue state can be abstracted well. Availability and effectiveness of the developed multi-sensors system were quite well for continuous monitoring of various physical conditions and health care of personals.