Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies

该项目将开发和使用新的中子和x射线散射方法来研究自然调节生化过程的分子机制。健康的功能需要细胞严格控制和协调无数的分子活动。我的研究重点是细胞内一系列相互依赖的分子网络，这些网络的行为由所谓的“第二信使”控制，它们将外部信号转化为正确的细胞反应。提出的实验将提供一个独特的结构框架，通过它我们可以了解这些信号是如何传输的。这些知识是生物医学研究和生物技术应用取得进展的重要基础。

This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that translate external signals into the right cellular responses. The proposed experiments will provide a unique structural framework by which we can understand how these signals are transmitted. Such knowledge is an important foundation for advances in biomedical research and biotechnology applications.