DEEP DRILLING OF THE HUMAN PLASMA PROTEOME

就像关掉城市的灯可以让你更清楚地看到暗淡的星星一样，从人体生物体液中去除高丰度的蛋白质可以让生物标志物的发现取得巨大飞跃。该项目将开发产品，以消除蛋白质组学的最大障碍-高丰度蛋白质（城市之光）。廉价、高效和常规地去除大量蛋白质将会增强？前沿?蛋白质组学技术在新生物标志物发现中的应用。这是可能的，因为在人类诊断液中存在未被发现的低拷贝数生物标志物（暗星），其水平远低于目前蛋白质组学阵列的检测极限。

Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers. This is possible because undiscovered low copy number biomarkers (faint stars) exist in human diagnostic fluids at levels far lower than current proteomic array detection limits.