Clinical Studies on Radiation Tolerance Doses

利用从日本许多研究所获得的数据，试图通过分析剂量反应曲线来估计各种器官的辐射耐受剂量。耐受限度是一个临床概念。耐受性的定义和估计并发症风险百分比所需的观察期取决于原发性恶性肿瘤的严重程度。本研究为回顾性研究。因此，没有获得足够数量的数据来估计各种正常组织的耐受剂量和时间-剂量关系。利用许多研究所当前治疗的标准条件，估计了几种正常组织的耐受水平：眼的耐受量大于Rubin和Casarett报道的耐受量，而口腔粘膜，皮肤和blase与Rubin和Casarett报道的一样大;以甲状腺功能减退为终点估计的甲状腺耐受性小于Rubin和Casarett报道的。

An attempt has been made to estimate the radiation tolerance doses for various organs on analysis of dose response plots, using data obtained from many institutes in Japan. The limits of tolerance is a clinical concept. The difinition of the tolerance and the observation period which is necessary to estimate the persentage for the risk of complication, are dependent on the severity of primary malignant tumor. And this study was retrospective one. Therefore, a sufficient number of data was not obtained to estimate the tolerance doses and time-dose relationships for all kind of normal tissues.Utilizing the standard set of conditions of current-day treatment in many institutes, the tolerance levels for several normal tissues were estimated : the tolerance dose for eye was larger than that reported by Rubin & Casarett, while those for oral mucosa, skin and blase was as large as those reported by Rubin & Casarett ; the tolerance of thyroid, estimated using hypothyroidism as an end point, was smaller than that reported by Rubin & Casarett.