Study on Threshold Limit Values of Occupational Allergens

首先，我们证明只有8个国家有职业性过敏原的清单或说明，即使在这些国家，也没有设定通过个人交流和查阅一些报告来接触这些过敏原预防过敏性疾病的阈值限值。接下来，我们建立了一套用于预测和测定职业性过敏性物质的剂量-反应关系的实验系统，该系统由测试样品的产生和调节装置、曝光室、体容计、p传感器、放大器和呼吸频率记录器组成，改进了Karol的模型，并以TDI为测试物质进行了上述动物(豚鼠)实验，证明了该模型的适用性。过敏反应的程度取决于吸入致敏浓度，但0.02ppm TDI暴露时未观察到呼吸道免疫反应，在该浓度下可观察到皮肤免疫反应。第三，我们通过对接触这些物质的工人进行现场过敏调查，明确了鸡毛和花的过敏反应可能导致人体即刻过敏。

First, we proved that there were only 8 countries which had the list or remark on occupational allergens and even in those countries no threshold limit values was set for preventing allergic diseases by an exposure to those allergens through personal communications and referring some reports. And we made a proposal of a new list of 80 substances for occupational allergens.Next, we deviced an experimental system for a prediction and determination of it's dose-response relationship of occupational allergic substances, consisted of an equipment of generation and regulation of a test sample, exposure chamber, body-plethysmogramm, p-transducer, amplifier and recorder for respiratory rates, improving Karol's model, and proved it's appropriateness for that purpose by conducting an animal (guinea pigs) experiment of above mentioned using TDI as the test substance. It was also indicated that the grade of allergic reaction was depending on inhalative concentrations for sensitizing exposures and, nevertheless no respiratory immune reaction was observed by an exposure of 0.02 ppm TDI, skin immune reaction was observed at that concentration.Third, we made it clear that a feather of chicken and flower of statice might cause human immediate allergic condition through conducting a field survey on allergy among workers handling those substances.