Correlation between surface force and morphology of self-assembled monolayer

金硫醇自组装单层膜作为一种最具潜力的不改变生物分子功能的固体载体，在表面制备方面得到了广泛的研究。在本项目中，我们将利用新合成的硫醇衍生物制备功能单层，利用表面力仪评估表面力与表面形貌之间的相关性，并优化制备免疫传感器等生物器件的条件。

As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the condition to fabricate biological devices such as immune sensors.