Drug Delivery System of Insulin and Calcitonin through the Scrotum of Rats.

为了阐明多肽药物通过阴囊的吸收机制，进行了药学、药理学和组织学研究。选择胰岛素和环孢素A作为模型肽，得到如下结果：胰岛素通过阴囊吸收：(1)在胰岛素溶液中不添加促进剂时，胰岛素几乎不能通过阴囊吸收。(2)通过加入氮酮和水杨酸，去除阴囊角质层，可大大增强胰岛素通过阴囊的吸收。用胶带去除角质层也增强了胰岛素的吸收，表明角质层作为运输屏障的重要性。(3)离子透入可增强吸收，但同时存在皮肤刺激和皮肤损伤。环孢素A通过阴囊的吸收：(1)同时给药氮酮和二甲基亚砜可以促进环孢素A的吸收，但在没有任何促进剂的情况下吸收有限。(2)组织学观察表明角膜吸收与角膜厚度呈正相关。

In order to clarify the absorption mechanism of peptide drugs through the scrotum, pharmaceutical, pharmacological, and histological studies were performed. Insulin and cycolsporin A were selected as model peptide, and following results were obtained.1. Absorption of Insulin through the Scrotum: (1) Insuliin was hardly absorbed through the sctotum of rats when no enhancer was added in insulin solution. (2) The absorption of insulin throgh the scrotum was greatly enhanced by the addition of azone and salicylic acid which remove the corneum of scrotum. the removal of corneum with adhesive tape also enahanced the insulin absorption, indicating importance of corneum as a transport barrier. (3) The enhanced absorption was abserved when iontophoresis was used, however the skin irritation and ski damage were observed simultaneously.2. Absorption of Cyclosporin A through the Scrotum: (1) The absorption of cyclosporin A was enhanced by the concomitant administration of azone and dimethylsulfoxide, though its absourption was limited without any enhancer. (2) The histological obsevation indicated the correlation between absorption and thickness of corneum.