Development of New Synthetic Methods via Multi-Metallic Organic Compounds

1) Lewis酸介导氨基甲酸酯与γ -氧化烯丙基锡的反应及其在（<正-负>）-他汀合成中的应用^1酰基铵离子(2)与γ -氧取代烯丙基锡（1a）的Lewis酸介导反应得到了产率较高的氨基醇衍生物(3)和(4)；在某些情况下，实现了非常高的非对映选择性，该过程适用于合成（<正负b>） -他汀2)区域选择性通过Li， sn -掩膜和/或g -掩膜二烯醇酯合成α -或γ -氨基酸衍生物^2通过(a)在某些情况下用锂二烯醇酯处理二乙基偶氮二羧酸（DEAD）， (b) sn -掩膜二烯醇酯，可以以非常高的区域选择性制备α -或γ -氨基酸衍生物。或(c)基掩二烯醇酯。通过甲氧基铅化合物立体发散合成1,2 -二醇甲氧基铅与醛的反应仅通过改变路易斯酸生成1,2 -二醇或反异构体。

1) The Lewis Acid Mediated Reaction of Carbamates with gamma-Oxygenated Allyltin and its Application to (<plus-minus>) -Statine Synthesis^1The Lewis acid mediated reaction of acyliminium ions (2) with gamma-oxygen substituted allyltin (1a) gives the amino alcohol derivatives (3) and (4) in good yields ; in certain cases very high diastereoselectivity is achieved and the procedure is applied to the synthesis of (<plus-minus>) -statin2) Regioselective Synthesis of either alpha- or gamma-Amino Acid Derivatives via Li, Sn-Masked, and/or Ge-Masked Dienolates^2Either the alpha- or gamma-amono acid derivatives can be prepared with very high regioselectivity by treating diethyl azodicarboxylate (DEAD) with (a) lithium dienolates themselves in certain cases, (b) Sn-masked dienolates, or (c) Ge-masked dienolates.3) Stereodivergent Synthesis of 1, 2-Diols via alpha-Methoxylead CompoundsThe reaction of alpha-methoxyleads with aldehydes gives either syn-1, 2-diols or antiisomers by merely changing the Lewis acids.