Japan-Indonesia joint study on etiology and clinicopathology of breast cancer

临床病理研究：印度尼西亚大学医学院Cipto Mangunkusumo中心医院的研究揭示了分期的分布：1期仅占2%，2期占16%，3A期占23%，3B期占40%，4期占19%。相比之下，在日本，第一阶段和第二阶段占35 - 41%，第三阶段占13%，第四阶段占不到1%。这一特殊数字清楚地表明两国之间缺乏临床病理特征的可比性。因此，日本团队的病理学家和外科医生支持进一步改进诊断和治疗技术。应用免疫过氧化物酶技术对50例印度尼西亚患者的雌激素受体反应进行了评估，初步结果显示72%为雌激素受体丰富的乳腺癌，超过三分之二的中度分化患者雌激素受体阳性。印度尼西亚的病例对照研究：3年内成功收集的300例病例和600例对照的初步分析表明，与女性乳腺癌风险增加显著相关的因素包括农村地区、乳房外伤史、体重过轻、自然和诱导绝经、不经常（1-2次）怀孕、母乳喂养时间短、遗传性状相近、经常摄入油性食物（优势比：2.65）。这些发现根本不是结论性的，因为数据不是通过划分绝经状态来评估的。然而，对油性食物的阳性反应表明下一步饮食调查的重要性和必要性。日本病例对照研究：收集1990年6月至1991年5月在东京癌症研究所医院接受乳房检查的所有女性患者（5095人）的流行病学资料。病例将被定义为随后被诊断为患有乳腺癌的患者，对照组将从被诊断为完全没有癌症的患者中随机选择。截至1992年2月，有4800名患者的数据被储存在计算机中。少

Clinico-pathological study : The studies at Dr. Cipto Mangunkusumo Central Hospital, Medical School, Univ. of Indonesia revealed a distribution of stages : Stage 1 in only 2 %, Stage 2 in 16 %, Stage 3A in 23 %, Stage 3B in 40%, and Stage 4 in 19%. In contrast, in Japan, Stage 1 and 2 accounted for 35 - 41 %, Stage 3 for 13 %, and Stage 4 for less than 1 %. This particular figure clearly indicated the absence of comparability of clinico-pathological features between two countries. Accordingly, the pathologist and surgeon in the Japanese team supported further the improvement of diagnostic and therapeutic techniques. The response to estrogen receptor was assessed on 50 Indonesian cases by using immunoperoxidase technique with a preliminary result that 72 % was estrogen receptor-rich breast cancer and that more than two-third of patients with moderate differentiation showed estrogen receptor positivity.2. Case-control study in Indonesia : The preliminary analysis of 300 cases and 600 mat … More ched controls successfully collected in three years revealed that the factors significantly associated with an increased risk of female breast cancer are staying at rural area, history of breast trauma, underweight, natural and induced menopause, infrequent (1-2 times) pregnancy, brief breast feeding, close genetic traits, and frequent intake of oily foods (odds ratio : 2.65) as well. These findings are not conclusive at all, since data are not assessed by dividing menopausal status. Nevertheless, positivity with oily foods indicates the importance and necessity of dietary investigation as a next step.3. Case-control study in Japan : Epidemiological information were collected from all female patients (5, 095 in number) whose breasts were examined at Cancer Institute Hospital, Tokyo, from June, 1990 to May, 1991. Cases will be defined as such patients subsequently diagnosed as having breast cancer, and controls will be randomly selected from patients diagnosed as not having cancer at all. Data on 4, 800 patients were stored in computer as of February, 1992. Less