Japan-Indonesia joint study on etiology and clinicopathology of breast cancer

日本-印度尼西亚乳腺癌病因学和临床病理学联合研究

• 批准号: 04042013
• 负责人: OHNO Yoshiyuki
• 金额: $ 5.38万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04042013/
• 关键词: Indonesia; Breast cancer; Case-control study; Risk factors

In order to disclose the risk factors for female breast cancer in Indonesia, we conducted two case-control studies : the first in 1989-1991 and the second in 1992 and 1993. Cases and controls in these studies are defined as follows. Cases are female breast cancer patients who were newly diagnosed and histopathologically confirmed at Dr.C Mangunkusumo Central Hospital, University of Indonesia, and aged from 25-79 years old. Female breast cancer patients with other malignancies were excluded. Controls are hospital patients, who were matched for cases by sex, age within to 3 years, social class, and hospital admittance within to 3 months, and randomly selected from in- and out-patients at the above hospital. Epidemiologic information were collected by direct interview of the study subjects themselves at one room in the hospital by two nurses in the first study/ by two nutritionists in the second study which devotedly aimed to explore nutritional risk factors for breast cancer in females. … More The first study has successfully collected epidemiologic information for 300 cases and 600 controls. The second study is still on-going and collected epidemiological and nutritional data for 122 cases and 177 controls as of the end of January, 1994.Multivariate analysis (unconditional logistic regression analysis), conducted for the first study by menopausal status, revealed the following major findings. In Indonesia, females with past history of breast trauma, past episode of oral-contraceptive use, any cancer patients among relatives, daily drinking of whole-milk, and daily eating of fresh fruits were at significantly greater risk, but females with daily intake of cooked vegetables at significantly less risk of pre-menopausal breast cancer. By contrast, for post-menopausal breast cancer, menarche at 15 years old or later, regular menstruation at 30 years old or later, and daily drinking of whole-milk were significantly associated with an increased risk, whereas divorced or separated marital status, larger waist-hip ratio, and larger number of breast-fed children with a significantly reduced risk. Artificial menopause and smoking habit appeared to increase post-menopausal breast cancer risk. Less

为了揭示印度尼西亚女性乳腺癌的危险因素，我们进行了两次病例对照研究：第一次在1989-1991年，第二次在1992年和1993年。这些研究中的病例和对照定义如下。病例为在印度尼西亚大学Dr.C Mangunkusumo中心医院新诊断和组织病理学确诊的女性乳腺癌患者，年龄为25-79岁。女性乳腺癌患者与其他恶性肿瘤被排除在外。对照组为医院患者，按性别、年龄3年内、社会阶层和入院时间3个月内进行病例匹配，并从上述医院的住院和门诊患者中随机选择。流行病学资料的收集是通过直接访谈的研究对象自己在医院的一个房间，在第一个研究中由两名护士/在第二个研究中由两名营养学家，专门探讨营养的危险因素，在女性乳腺癌。 ...更多信息 第一项研究成功地收集了300例病例和600例对照的流行病学信息。第二项研究仍在进行中，收集了122例病例和177例对照的流行病学和营养资料，截至1994年1月底。在印度尼西亚，女性过去的历史乳房创伤，过去的事件口服避孕药的使用，任何癌症患者的亲属，每天喝全脂牛奶，每天吃新鲜水果的风险显着增加，但女性每天摄入煮熟的蔬菜在绝经前乳腺癌的风险显着降低。相比之下，对于绝经后乳腺癌，15岁或更晚的月经初潮，30岁或更晚的月经规律，每天饮用全脂牛奶与风险增加显著相关，而离婚或分居的婚姻状况，较大的腰臀比，以及母乳喂养的孩子数量较多，风险显著降低。人工绝经和吸烟习惯似乎增加绝经后乳腺癌的风险。少