Japan-Indonesia joint study on etiology of breast cancer

日本-印度尼西亚乳腺癌病因联合研究

• 批准号: 06042006
• 负责人: OHNO Yoshiyuki
• 金额: $ 2.62万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042006/
• 关键词: Indonesia; Breast cancer; Case-control study; Risk factors

In order to disclose the role of dietary factors in female breast cancer in Indonesia, we have been conducting a case-control study in Jakarta, since 1992. This study is still on-going and collected epidemiological and nutritional data for 150 cases and 300 controls as of the end of January, 1995. The preliminary analysis revealed the following findings. (a) Before marriage, cases consumed significantly more mineral, phosphorous and ferrum than controls. The amount of carbohydrate intake was significantly smaller among cases than among controls. (b) After marriage, cases appeared to digest more retinol and vitamin C than controls with statistical significance. More detailed analysis including multivariate logistic regression analysis will be undertaken, when the data is completely collected.We also analyzed the data from a case-control study for breast cancer, which was conducted in Cancer Institute Hospital, Tokyo, from 1990 to 1991. Following significant findings emerged : (a) A larg … More e number of livebirths was associated with a decreased risk in premenopausal women (odds ratio (OR) for 3 or more births relative to none : 0.24). (b) In premenopausal women, regular menstrual cycle increased the risk (2.50). (c) Current smokers experienced an increased risk (1.63). (d) Heavy weight was associated with a greater risk of postmenopausal breast cancer : OR for those weighing 70 kg or more relative to those weighing 50 kg or less being 4.82. (e) The later the age at first livebirth, the higher the postmenopausal breast cancer risk (2.85,3.54 for ages of 30-34 and 35 years and more relative to 24 years or less, respectively).When comparing the results in Tokyo and in Jakarta, common risk factors are later age at first marriage in pre- and post- menopausal women, and smoking/heavy weight in postmenopausal women. Country-specific risk factors are as follows. Later age at menarche was associated with postmenopausal breast cancer in Jakarta, but was not in Tokyo. A large number of livebirths revealed a protective effect mainly for premenopausal breast cancer in Tokyo, while for postmenopausal one in Jakarta. Less

为了揭示饮食因素在印度尼西亚女性乳腺癌中的作用，自1992年以来，我们一直在雅加达进行病例对照研究。这项研究仍在进行中，截至1995年1月底收集了150例病例和300例对照的流行病学和营养资料。初步分析显示了以下结果。(a)婚前，病例组摄入的矿物质、磷和铁显著高于对照组。病例组的碳水化合物摄入量明显低于对照组。(b)结婚后，病例组的视黄醇和维生素C消化量明显高于对照组，差异有统计学意义。我们还分析了1990年至1991年在东京癌症研究所医院进行的乳腺癌病例对照研究的数据。出现了以下重大发现： ...更多信息 绝经前妇女的活产数与风险降低相关（3胎或3胎以上相对于无胎的比值比（OR）：0.24）。(b)在绝经前妇女中，规律的月经周期增加风险（2.50）。(c)目前吸烟者的风险增加（1.63）。(d)体重过重与绝经后乳腺癌的风险增加相关：体重70 kg或以上的人相对于体重50 kg或以下的人的OR为4.82。(e)首次生育年龄越晚，绝经后乳腺癌风险越高（30-34岁和35岁及以上相对于24岁或以下分别为2.85，3.54）。比较东京和雅加达的结果时，常见的风险因素是绝经前和绝经后妇女初婚年龄较晚，绝经后妇女吸烟/体重较重。具体国家的风险因素如下。在雅加达，月经初潮年龄晚与绝经后乳腺癌有关，但在东京则没有。大量的活产显示了保护作用，主要是绝经前乳腺癌在东京，而绝经后的一个在雅加达。少

项目成果

D Yjindarbmi, Ohno Y,Sakamoto G,Prihartono J,Jjahjadi G,Ramli M,Watanabe S,Darwis I,Budiningsih S,Suzuki S,Roostini E,Cornain S: "Ropanasuri" FAKTOR RISIKO TINGGI PADA KANKER PAYUDARA DI FKUI/RSCM. 22. 29-35 (1994)

D Yjindarbmi、Ohno Y、Sakamoto G、Prihartono J、Jjahjadi G、Ramli M、Watanabe S、Darwis I、Budiningsih S、Suzuki S、Roostini E、Cornain S：“Ropanasuri”FAKTOR RISIKO TINGGI PADA KANKER PAYUDARA DI FKUI/RSCM。

Kenji Wakai, Yoshiyuki Ohno, Susumu Wtanabe, Goi Sakamoto, Fujio Kasumi, Sadao Suzuki, Nakako Kubo-Fujiwara: "Journal of epidemiology" Risk Factors for Breast Cancer among Japanese Women in Tokyo : A Case-Control Sutdy. 4. 65-71 (1994)

Kenji Wakai、Yoshiyuki Ohno、Susumu Wtanabe、Goi Sakamoto、Fujio Kasumi、Sadao Suzuki、Nakako Kubo-Fujiwara：“流行病学杂志”东京日本女性乳腺癌的危险因素：病例对照研究。

Kenji Wakai,Yoshiyuki Ohno,Susumu Watanabe,Goi Sakamoto,Fujio Kasumi,Sadao suzuki,Nakako Kubo-Fujiwara: "Risk Factors for Breast Cancer among Japanese Women in Tokyo:A Case-Control Study" Journal of epidemiology. Vol.4. 65-71 (1994)

Kenji Wakai、Yoshiyuki Ohno、Susumu Watanabe、Goi Sakamoto、Fujio Kasumi、Sadao suzuki、Nakako Kubo-Fujiwara：“东京日本女性乳腺癌的危险因素：病例对照研究”流行病学杂志。

D.Tjindarbumi,Ohno Y,Sakamoto G,Prihartono J,Tjahjadi G,Ramli M,Watanabe S,Darwis I,Budiningsih S Suzuki S,Roostini E Cornain S,: "FAKTOR RISIKO TINGGI PADA KANKER PAYUDARA DI FKUI/RSCM" Ropanasuri. Vol.22. 29-35 (1994)

D.Tjindarbumi、Ohno Y、Sakamoto G、Prihartono J、Tjahjadi G、Ramli M、Watanabe S、Darwis I、Budiningsih S Suzuki S、Roostini E Cornain S，：“FAKTOR RISIKO TINGGI PADA KANKER PAYUDARA DI FKUI/RSCM”Ropanasuri。