Joint study on nutritional epidemiology of breast cancer

乳腺癌营养流行病学联合研究

• 批准号: 07042004
• 负责人: OHNO Yoshiyuki
• 金额: $ 2.11万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07042004/
• 关键词: Breast cancer; Case-control study; Indonesia; Risk factors; Nutrition; Fat; 脂肪

In order to disclose the role of dietary factors in female breast cancer in Indonesia, a case-control study has been undertaken including a nutritional interview in Jakarta since 1992. Epidemiological and nutritional information was collected for 226 cases and 452 controls as of the end of January, 1996. The preliminary analysis revealed the following findings. (a) The more the intake (per calorie) of protein, fat, calcium, phosphorus, retinol and ascorbic acid, the higher the risk of breast cancer. Remarkable positive association was detected particularly for fat intake. The odds ratios (ORs) for the second, third and fourth quartile, relative to the first quartile, were 2.66,4.28 and 5.52, respectively (trend p=2*10^<-9>). (b) In contrast, carbohydrate intake per calorie was strongly and negatively associated with the risk ; the corresponding ORs being 0.73,0.45 and 0.20, respectively (trend p=3*10^<-9>). These results, along with the findings obtained by our previous case-control study which used a food frequency method, suggest that excess fat intake may increase breast cancer risk in Indonesian females.

为了揭示饮食因素在印度尼西亚女性乳腺癌中的作用，自1992年以来，印尼进行了一项病例对照研究，其中包括在雅加达进行的一次营养访谈。截至1996年1月底，收集了226例病例和452例对照的流行病学和营养信息。初步分析揭示了以下发现。(A)蛋白质、脂肪、钙、磷、视黄醇和抗坏血酸的摄入量(按卡路里计算)越多，患乳腺癌的风险就越高。特别是在脂肪摄入量方面，发现了显着的正相关性。第二、第三和第四四分位数相对于第一四分位数的优势比(OR)分别为2.66、4.28和5.52(趋势p=2*10^-9)。(B)相比之下，每卡路里的碳水化合物摄入量与风险呈强烈的负相关；相应的OR分别为0.73、0.45和0.20(趋势p=3*10^&lt；-9&gt；)。这些结果，以及我们之前使用食物频率方法进行的病例对照研究的结果，表明过多的脂肪摄入可能会增加印尼女性患乳腺癌的风险。

项目成果

Dollon D,Herman S,Ohno Y,et al.: "Preliminary analysis of nutritional factors in breast cancer." Med J Indon. 4巻3号. 187-190 (1995)

Dollon D、Herman S、Ohno Y 等人：“乳腺癌营养因素的初步分析”，第 4 卷，第 3 期，187-190 (1995)。

Wakai K,Ohno Y,Suzuki S,Watanabe S,Sakamoto G,Kubo N.: "A case-control study of breast cancer among Japanese women in Tokyo." Med J Indon. 4巻3号. 177-182 (1995)

Wakai K、Ohno Y、Suzuki S、Watanabe S、Sakamoto G、Kubo N.：“东京日本女性乳腺癌病例对照研究”，《Med J Indon》第 4 卷，第 3 期。177-182 (1995)

Suzuki S,Prihartono J,Ohno Y,et al.: "Epidemiologic risk factors for breast cancer related to menopausal statusin Indonesea." Med J Indon. 4巻3号. 169-176 (1995)

Suzuki S、Prihartono J、Ohno Y 等人：“印度尼西亚与绝经状态相关的乳腺癌流行病学危险因素”，第 4 卷，第 3 期，169-176（1995 年）。

Tjindarbumi D,Ramli M,Watanabe S,et al.: "Clinicopathological aspects of breast cancer:a joint study between Indnesia and Japan." Med J Indon. 4巻3号. 148-155 (1995)

Tjindarbumi D、Ramli M、Watanabe S 等人：“乳腺癌的临床病理学方面：印度尼西亚和日本之间的联合研究”，第 4 卷，第 3 期。148-155 (1995)

Suzuki S,Prihartono J,Ohno Y,et al.: "Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia." Med J Indon. 4 (3). 169-176 (1995)

Suzuki S、Prihartono J、Ohno Y 等人：“印度尼西亚与绝经状态相关的乳腺癌流行病学危险因素。”