Measurement of Retino-Cortical Conduction Time using Pattern Reversal Stimulation for Detection of Subclinical Visual Dysfunction.

1. 167名健康受试者的瞬态模式反转视觉诱发电位。研究对象包括71名男性和96名女性。平均年龄45.7 +19.1岁。采用三种止回尺寸；15、30和60分钟。测量参数包括VEP潜伏期（P50、N75、P100、N145）和VEP振幅（N75、P100、N145）。与VEP检查30或60分钟相比，VEP模式检查至15分钟显示出明显延长和更大的反应。VEP潜伏期与年龄呈曲线相关。VEP振幅与头围呈负线性相关。与女性相比，男性模式VEP的反应时间明显延长，反应时间明显缩短。114例健康受试者的瞬态/稳态逆转型ERG/VEP研究114例健康受试者的平均年龄为45岁。采用两种模式反转率；0.8 Hz（瞬态）和5hz（稳态）。使用的检查尺寸分别为15分钟、30分钟和60分钟。使用放置在下眼睑的两个金箔电极记录ERG。瞬态ERG由a(p)、b(p)和c(p)组成。瞬态VEP由P50、N75、P100和N145组成。稳态ERG出现N1、P1、N2、P2、N3和P3峰。稳态VEP表现出NI、PI、NII、PII、NIII和PIII的峰值。瞬态或稳态ERG/VEP潜伏期与年龄呈曲线相关。视网膜皮质时间与年龄也呈曲线相关。瞬态/稳态ERG振幅随年龄增加而减小。VEP振幅随头部周长的增大而减小。多发性硬化症、视神经炎和HTLV-I相关脊髓病的模式逆转ERG/VEP异常有三种类型；(1) ERG正常，VEP延长；(2)ERG减少或缺失，VEP延长；(3)ERG和VEP均无反应。我们目前的研究有助于(1)理解视觉系统的正常生理知识，(2)有效和非侵入性地检测亚临床视觉系统疾病。

1. Transient pattern reversal visual evoked potentials in 167 healthy subjects.The subjects consisted of 71 males and 96 females. Their mean age was 45.7 +19.1. A three kinds of check size was used ; 15, 30 & 60 minutes. Measuring parameters consisted of VEP latencies (P50, N75, P100, N145) and VEP amplitudes (N75, P100, N145). Pattern VEP to 15 min checks showed significantly prolonged and larger responses, compared with VEP to 30 or 60 min checks. VEP latency and age showed curvilinear correlation. VEP amplitude and head circumference showed a negative linear correlation. Pattern VEP in males showed significantly prolonged and smaller responses, compared with VEP in females.2. Transient/Steady-state pattern reversal ERG/VEP in 114 healthy subjectsThe mean age of the 114 healthy subjects was 45 years. Two kinds of pattern reversal rates were used ; 0.8 Hz (transient) and 5 Hz (steady-state). Check sizes used were 15, 30 & 60 minutes. ERG was recorded using two gold-foil electrodes placed in lower eyelids. Transient ERG consisted of a(p), b(p) and c(p). Transient VEP consisted of P50, N75, P100 and N145. Steady-state ERG showed peaks of N1, P1, N2, P2, N3 & P3. Steady-state VEP showed peaks of NI, PI, NII, PII, NIII & PIII. Transient or steady-state ERG/VEP latencies showed a curvilinear correlation to age. Retino-cortical time and age showed a curvilinear correlation, too. Transient/steady-state ERG amplitudes decreased with increasing age. VEP amplitudes decreased with increasing head circumference.3. Pattern reversal ERG/VEP in multiple sclerosis, optic neuritis and HTLV-I associated myelopathy.There were three types of abnormalities ; (1) normal ERG and prolonged VEP, (2) reduced or absent ERG and prolonged VEP, (3) absent responses in both ERG & VEP.Our present study contributes to (1) understanding of normal physiological knowledge of visual system, and (2) effective and non-invasive detection of subclinical visual system disorders.