Inhibition of tumor neovascularizatuon in the experimental brain tumors by hydrocortisone.

肿瘤微循环不仅对肿瘤组织的代谢和行为具有重要意义，而且对肿瘤的治疗也具有重要意义。通过血管腐蚀模型的扫描电镜和免疫细胞化学研究，证明了氢化可的松对乙基亚硝基脲诱导的脑肿瘤新生血管的抑制作用。虽然在氢化可的松治疗的大鼠中观察到肿瘤发育率降低，但微血管结构和溴脱氧尿苷（BrdU）标记的内皮细胞在使用或不使用氢化可的松治疗时没有变化。在直径小于2mm的肿瘤中，未观察到肿瘤血管和BrdU标记的内皮细胞，表明肿瘤生长处于无血管期。另一方面，在直径大于2mm的肿瘤中，观察到不同的血管期。特别是肿瘤外周区血管扩张和弯曲，并伴有丰富的BrdU标记内皮细胞，这可能是血管生成的特征。

Tumor microcirculation is of crucial importance not only for the metabolism and behavior of tumor tissue but also for tumor therapy. Scanning electron microscopy of vascular corrosion casts and immuno- cytochemical study was undertaken to demonstrate the inhibition of the tumor neovasucularization by hydrocortisone in ethyinitrosourea induced brain tumors. Although a reduction in tumor developmental rate was observed in rats treated with hydrocotisone, microvascular architecture and bromodeoxyuridine(BrdU) labeled endothelial cells did not varied with or without hydrocortisone. In tumors less than 2mm in diameter no tumor vessels and BrdU labeled endothelial cells were observed, indicating an avascular phase of tumor growth. On the other hand, in tumors more than 2 mm in diameter, various vascular phases were observed. In particular, the peripheral zone of the tumors consisted of dilated and tortuous vessels and rich BrdU labeled endothelial cells which may be characteristic of angiogenesis.