Role of brain natriuretic peptide in arterial pressure regulation

脑和交感神经系统在心血管调节中起着重要作用。据报道，中枢应用心钠素(ANP)可对抗中枢应用血管紧张素(A)II的升压反应。最近，在猪脑中发现了两种新的利钠肽，分别称为脑利钠肽(BNP)和C型利钠肽(CNP)。为了研究BNP或CNP对血压的中枢作用，我们将BNP或CNP注入大鼠第三脑室，并测定了非肌动蛋白麻醉大鼠的动脉血压(AP)和血浆加压素(VP)浓度。1.尽管大剂量的BNP或CNP可降低AP，但静脉给药时，这些剂量也同样降低AP。血浆VP含量降低。2.脑室注射高渗盐水或AII可使AP和血浆VP显著升高。但BNP或CNP可抑制AP和VP对高渗盐水或AII的反应。法国巴黎银行或法国中央银行的这些中枢作用我们…更多的Re相当于ANP。3.复制盐敏感型高血压Dahl-S大鼠模型。中枢注射大剂量BNP可显著降低AP，但静脉给药时，这些剂量显示出相似的降压作用。此外，中枢应用BNP不影响压力感受器介导的反射功能。这些数据表明，在大脑中，BNP或CNP以及ANP通过对血压和VP分泌的影响而拮抗AII或NaCl。已有报道称循环AII可刺激SN活动，ANP可能拮抗对AII的SN反应。为了研究循环AII和ANP对血压和SN活性的相互作用，我们通过静脉滴注AII和ANP，并测定了AP和肌肉SN的活性。静脉注射AII可增强SN的活性，但同时注射ANP可减弱这种反应。虽然循环ANP对抗循环AII的作用机制尚未阐明，但我们的研究表明，这可能与脑内两种多肽之间的相互作用有关。较少

The brain and sympathetic nervous (SN) system play important roles in cardiovascular regulation. Central administration of atrial natriuretic peptide (ANP) has been reported to oppose pressor response to centrally administered angiotensin (A) II. Recently, two new types of natriuretic peptides were found in the porcine brain, termed brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). To examine the central action of BNP or CNP on blood pressure, we infused rat-BNP or CNP into the third ventricle and measured arterial blood pressure (AP) and plasma vasopressin (VP) concentration in inactin-anesthetized rats. 1. Although high doses of BNP or CNP produced reductions in AP, these doses, when given intravenously, similarly decreased AP. Plasma VP was decreased. 2. Hypertonic saline or AII given to the ventricle produced significant increases in AP and plasma VP. But BNP or CNP inhibited AP and VP responses to hypertonic saline or AII. These central actions of BNP or CNP we … More re equivalent to those of ANP. 3. Salt-sensitive hypertensive Dahl S rats were subjected. Central administration of high doses of BNP caused significant decreases in AP, but these doses, when given intravenously, showed similar depressor effects. Furthermore, centrally administered BNP did not affect the baroreceptor-mediated reflex function. These data suggest that, in the brain, BNP or CNP as well as ANP antagonizes AII or NaCl in terms of the effects on blood pressure and VP secretion.Circulating AII has been reported to stimulate SN activity, and ANP may antagonize the SN response to AII. To investigate the interactions between circulating AII and ANP for blood pressure and SN activity, we did intravenous infusions of AII and ANP and measured AP and muscle SN activity in human. Intravenous infusions of AII enhanced SN activities but simultaneous infusions of ANP attenuated the responses. Although the mechanism by which circulating ANP opposes the actions of circulating AII has not been elucidated, it could be related to the interaction between the two peptides in the brain as shown in our studies. Less