Antitumor Effects of Flutamide on Experimental Esophageal Carcinoma Induced by N-Amyl-N-Methylnitrosamine (AMN) in Rats

据了解，男性食管癌的发病率约为女性的4倍，女性食管癌切除术后的预后明显好于男性。人体皮肤是雄激素靶器官之一，人体皮肤细胞质的雄激素结合能力已被测定。由于食管黏膜与人类皮肤一样由鳞状上皮组成，因此推测性激素，特别是雄激素可能在食管粘膜细胞增殖和癌变过程中起重要作用。我们一直在研究性激素对食管癌发生的可能影响，这些影响是在饮水中给予n - amyl - n -甲基亚硝胺（AMN）的大鼠。本研究中，完整大鼠和去势大鼠分别给予AMN和氟他胺后，癌的发生率明显低于单独给予AMN的完整大鼠，在给予AMN后给予氟他胺的完整大鼠和去势大鼠食管癌的发生率略低于给予AMN后未给予氟他胺的完整大鼠。由此推测氟他胺可能对AMN诱导的实验性食管癌有抗肿瘤作用。

It is known that the incidence of carcinoma of the esophagus in men is about four times higher than that in women, and the prognosis after resection of esophageal carcinoma is substantially better in women than it is in men. Human skin is one of the androgen target organs and the androgen binding capacity of human skin cytosol has been measured. Since the esophageal mucosa consists of squamous epithelium the same as human skin does, it was speculated that sex hormones, androgen in paticular, might play an important role in cell proliferation of the esophageal mucosa and in carcinogenesis. We have been investigating the possible effects of sex hormones on the carcinogenesis of esophageal carcinoma in rats that were given N-Amyl-N-methylnitrosamine (AMN) in drinking water. In the present study, the incidence of carcinoma in intact and castrated rats administered AMN with flutamide was sign ificantly lower than that of intact rats administered AMN alone, and the incidence of esophageal carcinoma in intact and castrated rats that were given flutamide after administration of AMN was a little lower than that of intact rats were not given flutamide after administration of AMN. From this investigation, we speculate that flutamide may have antitumor effects on experimental esophageal carcinoma induced by AMN in rats.