Pathogenicity of Pneumonia Virus of Nice (PVM) in Immunodeficient Rats.

[1]采用间接荧光抗体法在日本实验动物群体中检测小鼠肺炎病毒（PVM）抗体。结果表明，该抗体在SPF大鼠中存在，发病率高。在家兔中也检测到该抗体。但在日本小鼠血清中未发现PVM抗体。这些结果表明，在日本，PVM感染存在于实验室大鼠而不是小鼠中。这一现象与西方国家有很大的不同，并指出了我国对PVM设施和养殖场进行微生物监测的重要性病毒分离试验结果为阳性，新分离物（31N等）的特征与NO相同。15;标准类型的PVM。将31N感染小鼠（ICR, *， 4周龄）和大鼠（wistar, *， 3周龄）进行动物实验。结果显示，31N诱导肺内实变。此外，该菌株还可引起小鼠和大鼠的间质性肺炎。该菌株在小鼠中的严重程度比大鼠更重。因此，大鼠的病理组织学变化对动物实验研究者和动物设施管理具有重要意义。

[1] Indirect fluorescent antibody method was applied for a detection of pneumonia virus of mouse (PVM) antibody in colonies of laboratory animals in Japan. The results showed that the antibody exist in SPF rats with high incidence. The antibody was also detected in rabbits. However, PVM antibody wasnot demonstrated in the sera of mouse in Japan.These results suggested that PVM infection is present in laboratory rats rather than mice in Japan. This phenomenon was very different from western countries, and pointed out the importance of microbiological monitoring for PVM in facilities and breeders in our country.[2] A trial of virus isolation was resulted in positive The characteristics of new isolates (31N and so on) was the same as the NO. 15 ; standard-type of PVM. 31N was infected to mice (ICR, *, 4-weeks old) amd rats (wistar, *, 3 weeks-old) for an animal experimentation.In the results, 31N induced the consolidation in lung. Also, the strain induced interstitial pneumonia in mice and rats. The severity by the strain was heavier in mice than rats.As a result, the patho-histological changes in rats were very important to investigators of animal experimentation and management of animal facility.