Integrative analysis of physiological adaption to environmental stress.

本合作研究的目的是从不同角度分析生物体对环境胁迫的适应机制，获得生理适应的整体观。作为调节反应，从体温调节、循环调节、体液调节、代谢等方面，从单细胞到全身和行为，对适应机制进行了研究。作为控制因素，还涉及神经系统、内分泌系统以及与免疫系统的关系，研究的主题包括外周总阻力与中心静脉压的关系，局部加热时皮肤血流量的调节，皮肤血流量与交感神经活动的关系，发热与交感神经活动的区域反应，杀神经节药对棕色脂肪组织产热的作用，肽和细胞因子对体液和循环功能调节的作用，LPS、IL-1和热应激对巨噬细胞活性的作用，CNS中的儿茶酚胺对昼夜节律的作用，边缘系统对空间识别的作用，在研究期间召开了两次学术会议，在介绍这些研究成果的基础上，就环境胁迫适应性反应的综合观点、这些反应之间的相互作用、适应功能的层次结构、以及这些适应性变化的控制机制。讨论对小组的每一位成员都很有启发性，并将对他们的工作产生反馈作用，也将通过他们发表的著作对环境生理学家产生反馈作用。

The aim of this Cooperative research was to analyze the adaptive mechanism of living organism to environmental stresses from different aspects, and to obtain the integrative view of physiological adaptation. As the regulatory responses, the adaptive mechanisms were studied from body temperature regulation, circulatory adjustments, body fluid regulation, and metabolism using from single cell to whole body and behavior. As the controlling factors, involvements of nervous system, endocrine system and the relationship with immune system were also covered.Themes studied include the relationship between total peripheral resistance and central venous pressure, regulation of skin blood flow during local heating, the relationship between skin blood flow and sympathetic nervous activity, fever and the regional response of sympathetic nervous activity, the effect of gangliocides on the thermogenesis of brown adipose tissue, the effects of peptides and cytokines on the regulation of body fluid and circulatory functions, the effects of LPS, IL-1 and heat stress on the activity of macrophage, the role of catecholamine in CNS on circadian rhythm, the role of limbic system on space recognition, and the morphological changes of nerve cell due to ECF changes.Scientific meetings were held twice during the research period, and based on the presentations of these research works, lively discussions were made on the integrative view of these adaptive responses to environmental stress, interactions of these responses, the hierarchic structure of adaptive functions, and the control mechanism of these adaptive changes.The discussion was very stimulating to each member of the group, and will have feedback effects on their work and also to the environmental physiologists through their published works.