Studies on the relationship between demyelination and non-immnologically induced Ia antigen.

为阐明主要组织相容性复合物II类（Ia）抗原在中枢神经系统（CNS）沃勒变性后小胶质细胞中诱导的意义，将实验性变应性脑炎（EAE）过继转移到刘易斯大鼠，其中Ia抗原已在沃勒变性部位的小胶质细胞中诱导。此外，对于随机分布的典型EAE病灶，受体大鼠出现了明显的炎性病变，与Ia阳性小胶质细胞的分布雅阁;例如，皮质损伤后同侧丘脑及单侧眼球摘除后同侧视神经、对侧视束及上丘的变化。因此，EAE基因座可以通过这种方法靶向。当用淋巴细胞的单克隆抗体表面标记物检查时，淋巴细胞的类型与脊髓中普通EAE病变中的淋巴细胞类型没有区别。非免疫诱导的Ia阳性细胞簇作为自身免疫性CNS疾病的靶点的潜在作用进行了讨论。

To clarify the Implication of the major histocompatibility complex class II(Ia)antigen Induction In microglia following the Wallerian degeneration in the central nervous system(CNS), experimental allergic encephalitis(EAE)was adoptively transferred to Lewis rats In which Ia antigens had been Induced in microglia at the sites of Wallerian degeneration. In addition, to randomly distributed typical EAE lesions, the recipient rats developed distinct inflammatory lesions In accord with the distribution of Ia-positive microglia ; l. e., In the ipsilateral thalamus after cortical injury, and In the Ipsilateral optic nerve, the contralateral optic tract and superlor colliculus after unilateral eye ball enucleation. Thus, the EAE locus may be targeted by this approach. When examined using monoclonal antibody surface markers of lymphocytes, the types of lymphocytes did not differ from those In ordinary EAE lesions In the spinal cord. The potential role of nonlmmunologically induced Ia-positive cell clusters that serve as a target for autoimmune CNS diseases was discussed.