Coupling mechanism of mechano-sensing and cellular reactivity in the process of stretch activation of vascular tissue.

血管系统不仅是化学接受的场所，也是机械接受的场所，这些刺激引起随后的细胞反应，如收缩和松弛。对拉伸特别敏感的脑、冠状动脉、淋巴管等血管组织在结构上具有相似性；低倾斜的肌层，质膜下发育良好的小窝，线粒体丰富。机械接受比药理接受更容易受到化学剥皮的影响，这表明膜脂作为机械传感器领域的重要性。磷脂酶C与gtp结合蛋白偶联，可能是G_q类，对霍乱或百日咳毒素不敏感，可能在快速拉伸产生血管张力的发生中起作用。血管对机械刺激的反应性可能是通过Ca^<2+>信号通路介导的，这是机械接受所特有的，也是传统血管收缩激动剂（如去甲肾上腺素）所共有的。

The vascular system is a site of not only chemical but also mechanical reception, and these stimuli elicit subsequent cellular responses such as contraction and relaxation. The vascular tissues such as cerebral and coronary arteries and lymphaticus, which are particularly sensitive to stretch, possess structural similarities ; lowpitched muscular lining, well-developed caveola beneath the plasma membrane, and abundant mitochondria. The mechanical reception is more susceptible than pharmacological reception to chemical skinning, suggesting the importance of membrane lipids as a mechanosensor domain. Phospholipase C coupled to GTP-binding protein, possibly a G_q class, which is insensitive to cholera- or pertussis toxin, may play a role in the genesis of vascular tone produced by quick stretch. The vascular reactivity to a mechanical stimulus may be mediated through the pathways of Ca^<2+> signaling which are specific to the mechano-reception and common to a conventional vasoconstrictive agonist such as norepinephrine.