Role of Kupffer cell in the regulation of hepatic metabolism.

酵母多糖颗粒诱导葡萄糖产生和前列腺素（PG）释放到灌流液中的增加。酵母多糖颗粒诱导的反应可被环氧合酶抑制剂抑制。PG释放量与葡萄糖生成量的相关系数分别为r=0.87（PGF_2）和r=0.83（PGD_2）。酵母多糖或甘露聚糖在灌流的大鼠肝脏中诱导双相葡萄糖输出和抑制氧消耗。脂氧合酶抑制剂或白三烯（LT）D_4受体拮抗剂可抑制这些变化，而环氧合酶抑制剂则无此作用。在输注甘露聚糖后再输注酵母多糖可使第二反应脱敏，表明酵母多糖中富含甘露聚糖。刺激肝神经可引起葡萄糖生成增加，并可被环氧合酶抑制剂抑制，但不影响去甲肾上腺素溢出。这些结果表明，酵母多糖颗粒诱导糖原分解通过PG生产和甘露糖受体激活导致肽LT合成。

Zymosan pellet induced an increase of glucose production and release of prostanoid (PG) into the perfusate. Zymosan pellet-induced responses were inhibited by cyclooxygenase inhibitor. Possible correlation of the PG release and glucose production were r=0.87 (PGF_2) and r=0.83 (PGD_2), respectively. Zymosan sup or mannan induced a biphasic glucose output and suppression of oxygen consumption in perfused rat livers. These changes were inhibited by lipoxygenase inhibitor or leukotriene (LT) D_4 receptor antagonist, but not cyclooxygenase inhibitor. Sequentially infused zymosan sup after mannan infusion showed the desensitization of second responses, indicating that zymosan sup was rich in mannan. The stimulation of hepatic narve stimulation induced an increase of glucose production and was inhibited by cyclooxygenase inhibitor without affecting norepinephrine overflow. These results suggest that zymosan pellet induces glycogenolysis via PG production and that mannose receptor activation causes peptide-LT synthesis.