Hybridization of Functional Bioabsorbable Polymers with Bioactive Compounds and Biocells

采用3-(s)-[（苄基氧羰基）甲基]-1,4-二恶烷-2,5-二酮（BMD）与l -丙交酯共聚合成了含有苹果酸的新型聚-羟基酸。所得到的共聚物（α -羟基酸）（PMLA），由乙醇酸(G)， α -苹果酸(M)和L-乳酸(L)组成，由于悬垂的羧基的作用，水解速率加快。这些羧基也被用作化学修饰的位点，以获得具有预期功能的生物可吸收聚合物。本实验采用DCC法将RGD三肽固定在这些羧基上，以增强细胞的附着性。PGML。这种rgd -固定化的生物可吸收聚合物和生物细胞的混合材料在引导组织再生（GTR）技术上具有很高的发展潜力，在这种技术中，在特殊设计的生物可降解聚合物基质上诱导和控制人体组织的再生。分析了聚合物腐蚀对细胞附着和生长的影响。

A new poly(alpha-hydroxy acid) comprising alpha-malic acid was synthesized by copolymerization of 3-(s)-[(benzyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione (BMD) and L-lactide followed by deprotection of the benzyl groups by hydrogenolysis. The resultant copoly(alpha-hydroxy acid)(PMLA), consisting of glycolic acid (G), alpha-malic acid (M), and L-lactic acid (L) units, showed an accelerated hydrolysis rate due to the action of the pendant carboxyl groups. These carboxyl groups were also utilized as the sites of chemical modification to obtain a bioresorbable polymer with intended functions. Here, RGD tripeptide was immobilized on these carboxyl groups by DCC method in order to enhance the cell attachment property. of PGML. The hybrid materials of this RGD-immobilized bioresorbable polymer and biocells have a high potential for developing guided tissue regeneration (GTR) technique in which regeneration of human tissue is induced and controlled on a specially designed biodegradable polymeric matrix. Also, the effect of polymer eroding on the cell attachment and growth was analyzed.