Japan-China Study on Genetic Factors for CVD Prevention

我们对中国所在的广东梅县进行了营养与心血管疾病遗传因素的流行病学研究，以预测和预防心血管疾病。调查对象为梅县地区客家人，男55人，女65人，年龄40~60岁，应答率78%，进行身高、体重测量、血压、24小时尿(24小时)采血、饮食及病史问诊。低体重指数(kg/m^2)(男：20.9；正负)(男：3.2，女：21.5；正负；2.6，均值)和相对较低的收缩压(男：127.7；正负)(男：19.0，女：122.6；正-负；20.4毫米汞柱)和舒张压(男：75.5；正-负；12.0，女性：70.3；正负；11.6)血压大于或等于&gt；160和/或舒张压大于或等于&gt；95和/或服用抗高血压药物的高血压(HT)患者发生率低。24HU钠(Na)排泄量(男：158.5+-gt；68.3mEq/d，女：150.0&lt；+-gt；63.2mEq/d)在中国人群中处于较低水平。钾(K)(M：38.0；正负；20.7mEq/d，F：37.5；正负；15.5)不够高，Na/K值(M：4.7；正负；2.0，F：4.4；正负；1.9)未达到理想水平。24hu牛磺酸排泄量(男性：1437.7；+-gt；1160.4 mEq/d，女性：1721.3&lt；+-gt；1077.1)在中国人群中处于较高水平，但低于大量食用海产品的日本人群。牛磺酸可以来源于动物(猪、牛等)的肝脏和肾脏，也可以来自海鲜蛋白，梅县人经常摄入猪的内脏。我们从客家人中挑选了10个家系进行了HT基因分析，其中3个家系患有严重的HT

We conducted nutritional and cardiovascular disease (CVD) epidemiological study on genetic factors for CVD prediction and prevention in Meixian, Guangdong, People's Republic of China. Fifty-five males (M) and 65 females (F) at the age of 40-60 were recruited (78% response rate) from Hakka people living around Meixian area for height and body weight measurement, blood pressure (BP) , 24hour urine (24hu) collection, blood test and medical interview on diet and medical history. They showed low body mass index (Kg/m^2) (M : 20.9<plus-minus>3.2, F : 21.5<plus-minus>2.6, mean<plus-minus>SD) and relatively low systolic BP (SBP) (M : 127.7<plus-minus>19.0, F : 122.6<plus-minus>20.4 mmHg) and diastolic BP (DBP) (M : 75.5<plus-minus>12.0, F : 70.3<plus-minus>11.6) having low rate of hypertensive (HT) patient who showed SBP <greater than or equal>160 and/or DBP <greater than or equal>95 and/or on anti-HT medication. 24hu sodium (Na) excretion (M : 158.5<plus-minus>68.3 mEq/day, F : 150.0<plus-minus>63.2) was relatively low level among Chinese populations. Potassium (K) (M : 38.0<plus-minus>20.7 mEq/day, F : 37.5<plus-minus>15.5) was not high enough, so their Na/K ratio (M : 4.7<plus-minus>2.0, F : 4.4<plus-minus>1.9) did not reach ideal level. 24hu taurine (TAU) excretion (M : 1437.7<plus-minus>1160.4 mEq/day, F : 1721.3<plus-minus>1077.1) , which has beneficial effects against HT and atherosclerotic diseases, was relatively high level among Chinese populations, but less than Japanese populations taking a lot of sea-foods. TAU could be derived from liver and kidney of animals (pig, cow, etc.) , as well as sea-food protein, people in Meixian often intake pig's internal organs. We picked up 10 families from Hakka people for HT genes analysis, 3 of them had serious HT