Monitor system of cough and wheeging in bronchial asthma.

喘息、呼吸困难和咳嗽构成支气管哮喘的典型症状三联征，应激或催眠暗示可诱发哮喘发作，增加支气管高反应性。因此，催眠疗法被尝试作为哮喘的一种治疗方法，当使用超过12个月时，有一些好处。咳嗽被认为与神经精神疾病有关。癔球或焦虑反应可引起咳嗽。此外，咳嗽发生在与神经传递异常相关的神经系统疾病中，并与面部肩部抽搐有关，这可能是由于高级中枢对传入通路的不适当刺激所致。然而，促进咳嗽反应的学习效应尚未得到研究。为了确定心理因素是否会影响咳嗽反应，我们采用了一种经典的条件反射程序，在清醒的豚鼠中，辣椒素的刺激与气味的呈现相匹配。第1 ~ 4天，动物分别给予非条件刺激辣椒素气雾剂和条件刺激樟脑气雾剂（1组）、辣椒素和生理盐水气雾剂（2组）和樟脑和生理盐水气雾剂（3组），并统计咳嗽次数。第5天，各组均给予樟脑和生理盐水气雾剂。第5天，仅1组小鼠在单独暴露于该气味时出现了显著的咳嗽（p<0.01）。这表明联想学习增强了咳嗽反应。

Wheezing, dyspnea and cough constitute the triad of classical symptoms of bronchial asthma, and stress or hypnotic suggestion can provoke the attacks of asthma and increase bronchial hyperresponsiveness. Hypnotherapy has therefore been tried as a treatment for asthma and some benefits are reported when used over a period of 12 months. Cough is suggested to occur in association with neuropsychiatric causes. Globus hystericus or anxiety reaction may cause cough. Furthermore, cough occurs in a neurologic disorder associated with abnormal neural transmission and is associated with tics of the face shoulder, probably due to inappropriate stimulation of afferent pathways from higher centers. However, the learning effect that facilitates the cough response has not been studied. To determine whether psychological factors affect cough response, we employed a classical conditioning procedure in which capsaicin challenge was paired with the presentation of an odor in awake guinea pigs. On days 1 to 4, animals received combined administrations of the unconditioning stimulus capsaicin aerosols and the conditioning stimulus camphor aerosols (Group 1) , capasaicin and saline aerosols (Group 2) and camphor and saline aerosols (Group 3) , and the number of coughs was counted. On day 5, all groups received camphor and saline aerosols. A significant number of coughs (p<0.01) was observed only in Group 1 when the animals were exposed to the odor alone on Day 5. This suggests that associative learning enhances cough response.