Finding effective treatments for inhaled chlorine-induced injury related pain

寻找吸入氯引起的损伤相关疼痛的有效治疗方法

• 批准号: 8554915
• 负责人: Sadis Matalon
• 金额: $ 36.74万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8554915
• 关键词: Accidents; Adrenergic Agonists; Adrenergic Receptor; Adrenergic beta-Agonists; Adverse effects; Affect; Agonist; Anesthetics; Anti-Inflammatory Agents; Anti-inflammatory; Antidotes; Behavioral; Biochemical; Biochemical Markers; Breathing; Bronchial Spasm; Bronchoalveolar Lavage; Cardiovascular system; Caring; Cessation of life; Chemical Warfare; Chest Pain; Chlorine; Clinical; Clinical Treatment; Controlled Clinical Trials; Coronary Arteriosclerosis; Coughing; Coupled; Data; Devices; Dyspnea; Equipment; Evaluation; Event; Exposure to; Functional disorder; Gases; Hand; Hospitals; Hypoxia; Individual; Industrial Accidents; Inflammation; Injury; Irritants; Laboratories; Lidocaine; Literature; Local Anesthetics; Locomotion; Lung; Measurement; Measures; Medical; Methodology; Modeling; Morbidity - disease rate; Movement; Mus; Nebulizer; Neurologic; Nose; Opioid; Oral cavity; Oxygen saturation measurement; Pain; Pharmaceutical Preparations; Poisoning; Pump; Regimen; Respiration; Respiratory Failure; Respiratory physiology; Sampling; Sensory; Serum; Stridor; Structure; Structure of parenchyma of lung; Symptoms; System; Terrorism; Testing; Tissues; Toxic effect; Translating; Transportation; Vent; World War I; base; cardiopulmonary system; clinical practice; effective therapy; improved; irritation; lung injury; men; mortality; novel therapeutic intervention; pain behavior; planetary Atmosphere; respiratory; response; treatment effect

DESCRIPTION (provided by applicant): Chlorine (Cl2) is a highly irritant and reactive gas produced in large quantities throughout the world. Exposure to Cl2 released into the atmosphere during transportation and industrial accidents, as well as acts of terrorism, has resulted in significant lung injury leading to death from respiratory failure or significant morbidty. Our recent data show that there may be benefit to treating subjects exposed to Cl2 with inhaled local anesthetics. The present studies will examine the effects of this treatment as monotherapy or in combination with a beta adrenergic agonist on measures of pain and inflammation in murine models.

描述（由申请人提供）：氯（Cl2）是一种高度刺激性和反应性气体，在世界各地大量生产。暴露于在运输和工业事故以及恐怖主义行为期间释放到大气中的Cl2，会导致严重的肺损伤，从而导致呼吸衰竭或严重的发病死亡。我们最近的数据表明，吸入局部麻醉剂治疗暴露于Cl2的受试者可能有益。本研究将检查这种治疗作为单一疗法或与β肾上腺素能激动剂组合对小鼠模型中疼痛和炎症测量的影响。