Development and Quantitative Study of High-Strength Poly (vinyl Alcohol) Fiber for Medical Use

采用凝胶纺丝法制备了拉伸强度高的高强度聚乙烯醇纤维(简称HS-PVA)。植入试验表明，HS-PVA纤维比浸泡在PSS中的纤维强度和刚性下降更明显，经逐步干燥或强制干燥后不能恢复。注入75周的HS-PVA的结点强度下降到原来强度的40%左右，聚合度下降到90%左右。注入的HS-PVA的红外光谱在1600 cm~(-1)&gt~(-1)处有一个小峰，表明存在C=C键。虽然注入的HS-PVA表面大部分是光滑的，但扫描电子显微镜观察到分散的腐蚀和扭结。(操作特性)定量地证明了HS-PVA缝合线良好的操作特性，这可以用静态和动态拔出阻力的较大差异来解释。定量测定了HS-PVA和涤纶缝线的体内张力保持能力，显示了HS-PVA和涤纶缝合的优越性。

High-strength poly (vinyl alcohol) fiber (abbreviated HS-PVA) characterized by high tensile strength, was obtained by gel spinning method. The fiber might be fit to use as suture material for tight tying, artificial tendon, artificial ligament and reinforcing fiber for bio-composite materials without risk of residual cross-linking agents such as formalin.(Implantation testing) The strength and rigidity of the implanted HS-PVA fiber were decreased more markedly than that immersed in PSS,and could not restore by gradual or forced drying. The knot strength of the 75 weeks implanted HS-PVA was deteriorated to about 40% of original strength, while the polymerization degree to about 90%. The infrared spectroscopy of the implanted HS-PVA showed a small peak at 1600 cm^<-1>, which shows existence of C=C bond. Although the greater part of the implanted HS-PVA surface is smooth, scattered erosion and kink were observed by scanning electron microscopy. Localized dissolution by contacting cell was suggested.(Handling Characteristics) The excellent handling characteristics of HS-PVA suture were proved quantitatively, which could be explained in terms of a large difference between static and dynamic pullout resistances. In-vivo tension holding capacity was also measured quantitatively, which shows excellency of HS-PVA and Dacron suture.