Research for natural prognosis and surgical effect in thoracic and abdominal aneurysm

* 1992年和1993年，我们建立了兔体外循环（CPB）模型，研究了脑pH、颈内静脉饱和度（SjO2）和动脉血血红蛋白（Hb）的关系。接下来，我们将在接下来的实验中研究脑血流量减少、脑pH和氧合血红蛋白与脑损伤的关系。结果如下：1)低温CPB时脑pH升高，脑pH、Hb值与SjO2呈正相关（r=0.634, r=0.620）。2)血稀释越严重，脑pH酸中毒越严重。3)脑中脱氧血红蛋白随脑血流量的减少而增加，当脑血流量为30ml/kg/mi4时，其值为15.8 <正- > 11.9muM。* 1994年*我们测量并考虑了使用低低温CPB和单独脑灌注的心内直视手术患者的氧和脱氧hb。结果如下：1)成人患者在低温CPB过程中，oxyHb低于对照组（p<0.05），脱氧hb高于对照组（p<0.05）。2)儿童低体温CPB过程中，氧血红蛋白明显高于对照组。3)脑灌注流量与氧血红蛋白呈正相关。4)提示氧合血红蛋白和脱氧血红蛋白的测定可作为CPB过程中脑灌注的可靠监测指标

*In 1992 and 1993* We have established the cardiopulmoanry bypass (CPB) model of the rabbit, and we studied the relationship the brain pH,the saturation of internal jugular vein (SjO2) and the hemoglobin (Hb) in the arterial blood. And next, we have sudied the relationship the brain damage induced by the decreasing the brain blood flow, the brain pH and the oxyhemoglobin in the next experiment. Results were as followed ;1)The brain pH was elavated during the hypothermic CPB and the brain pH,the Hb value and the SjO2 indicated the positive correlation (r=0.634, r=0.620) .2)The more the blood dilition proceeded, the more the acidosis of brain pH.3)The deoxyHb in the brain was increaed according to the decreasing of the brain blood flow, and showed the value of 15.8 <plus-minus> 11.9muM when the brain blood flow was 30ml/kg/mi4)The brain pH showed the negative correlation with the deoxyHb.*In 1994* We measured and considered the oxy and deoxyHb in the open heart surgery using the hypothemic CPB and in the patients using the separate brain perfusion. Results were as followed ;1)The oxyHb showed the lower value than the control during the hypothermic CPB in adult patients (p<0.05) and the deoxyHb higher(p<0.05).2)The oxyHb showed significantly higher than the control during the hypothemic CPB in pediatric patients.3)The brain perfusion flow and the oxyHb showed the positve relationship.4)It was suggested that the measurement of the oxyHb and the deoxyHb would become the reliable monitor of the cerebral perfusion during the CPB