Epidemiological Study on Diet and Cancer among Japanese Brazilian

巴西进行了关于饮食和癌症的流行病学研究，巴西是一个拥有120万日本血统的多民族国家。在圣保罗对随机选择的日裔巴西人进行了一项饮食记录调查，并对191名受试者进行了为期3天的饮食记录。这些数据正在进行营养计算。对在利马随机选择的111名日本秘鲁人的饮食习惯以及从他们那里获得的食物频率数据和血液样本进行了横断面研究。巴西的一项肺癌病例对照研究表明，吸烟的风险与CYP1A1基因外显子7的多态性存在交互作用。巴西也进行了胃癌的病例对照研究。问卷调查数据采集了圣保罗地区101例日本人(63名男性，38名女性)和248名非日本人(179名男性，69名女性)胃癌患者及其对照的血液成分。幽门螺杆菌抗体分析和DNA提取用于基因分型。在非日本人的巴西人中，一生吸烟超过50包的人患胃癌的风险显著增加(与从不吸烟的人相比，OR=1.8)，但对日本人的巴西人来说，没有相关性。在两组人中，频繁食用油炸食品与风险增加相关，而日常牛肉消费仅在日本人巴西人中增加风险(与每月消费的OR=3.7)。经常摄入水果和蔬菜与降低患胃癌的风险有关，这种关联在非日本人巴西人中非常明显，他们比日本人吃水果和蔬菜更少。这些发现表明，风险因素在不同种族之间存在差异，可能与遗传背景和/或环境因素暴露水平有关。

Epidemiological studies on diet and cancer have been conducted in Brazil, a multi-ethnic nation with 1.2 million residents of Japanese ancestry.A dietary record survey was applied to randomly selected Japanese Brazilians in Sao Paulo and a 3 day dietary record obtained from 191 subjects.Nutritional caluculation is on-going for these data.A cross-sectional study of dietary habits was conducted in 111 randomly selected Japanese Peruvians in Lima and food frequency data and blood samples obtained from them.A case-control study of lung cancer in Brazil suggested that the risk of cigarette smoking interacted with the exon 7 polymorphism of CYP1A1.A case-control study of stomach cancer has also been done in Brazil.Questionnaire data blood components were collected from 101 Japanese (63 males and 38 females) and 248 non-Japanese (179 males and 69 females) cases of gastric cancer and their controls in the Sao Paulo area.The blood samples were used for laboratory assays such as pepsinogen measurement, Helicobactor pylori antibody analysis and DNA extraction for genotyping.Life-time cigarette consumption over 50 pack-years was significantly associated with increased risk of stomach cancer for non-Japanese Brazilians (OR=1.8 compared with never smoking), but not for Japanese Brazilians.Frequent consumption of fried food was associated with increased risk in both groups, while daily beef consumption increased the risk only in Japanese Brazilians (OR=3.7 compared with monthly consumption).In adittion, frequent fruit and vegetable intake was associated with reduced risk of stomach cancer and this association was remarkable in non-Japanese Brazilians who consumed less fruit and vegetables than Japanese Brazilians.These findings suggest that the risk factors vary among ethnic groups and may be related to genetic background and/or exposure levels of environmental factors.