Bone remodeling at the interface with biomaterials

植入材料的种类、材料的表面特性、植入的解剖位置和承重条件都影响着植入材料周围骨的形成和重塑。本研究将三种材料植入犬股骨髁，观察6个月骨形成和重塑。在珠膜氧化铝周围观察到均匀增厚的板层骨，而在光滑氧化铝周围形成被皮质化骨包围的厚纤维组织。利用有限元分析（FEA）对这种明显的重塑模式进行了力学模拟。虽然珠状涂层氧化铝周围的应力分布模拟了骨密度，但未涂层种植体周围的重塑模式不能由应力决定。为了描述后一种重塑模式，有必要分析种植体周围的应变。

Bone formation and remodeling around implanted materials are influenced by the kinds of materials, surface properties of the materials, anatomical sites of implantation, and the load-bearing condition. In this study, three kinds of materials were implanted into the femoral condyles of dogs, and bone formation and remodeling were observed for 6 months. Uniform thickening of lamellar bones was observed around bead-coated alumina while thick fibrous tissues surrounded by corticalized bones formed around smooth alumina. This distinct difference in remodeling pattern was subjected to mechanical simulation by using finite-element analysis (FEA) . Although stress distribution around bead-coated alumina simulates the bone density, the remodeling pattern around an uncoated implant could not be determined by the stress. To describe the latter remodeling pattern, it is necessary to analyze the strain surrounding the implants.