Self-limited controlling system for resolving fecal incontinence

在狗身上，我们首先研究了生理缺陷之前的结肠力学行为。为了实现这一目标，我们将四个应变片固定在结肠壁上，并记录和评估了清醒和非限制性动物通过管喂引起潜在地引起胃结肠反射的结肠机械活动。因此，与普通排便有关的机械性收缩在降结肠被证明是最明显的。另一方面，我们进行了另一项开发结肠电起搏技术的研究，因为在我们的实验中，基于管喂的现有方法并不总是导致随后的排便。在这项测试中，我们得出结论，从内部对结肠进行电刺激效果更好，最佳起搏条件是电压10伏，持续时间20毫秒，频率每分钟30次。我们的结果肯定支持我们的目标，即通过一种新的自我限制电路系统来控制大便失禁，该系统包括在肠道运动之前对结肠行为的早期感知，以及肛门括约肌的电连接FES(所谓的功能电刺激)，这不足以容纳混乱的粪便污染。

ABSTRACTUsing dogs, we first investigated colonic mechanical behavior specifically preceding physiological defection. To fulfilll this aim, four strain gaugages were fixed by suturing onto the colonic wall, and we recorded and evaluated colonic mechanical activities caused by tube feedings in awake and nonrestricted animals which potetially provoke gastrocolic reflex. As a consequence, mechanical contractions associated with ordinary defecation proved to be most prominent in the descending colon. On the other hand, another study for developing a technique of colonic electrical pacing was undertaken because current way based on tube feeding did not always led to subsequent defecation in our experiment. In this test, we concluded that electrical stimulation of the colon worked better when applied from inside, and the best pacing condition was specified as a combination of10 volts in voltage, 20 msec in duration, and 30 beats per minute in frequency. Our outcome is sure to support our goal of controlling fecal incontinence by a new self-limited circuit system consisting of an early perception of colonic behavior preceding bowel movements, and electrically-linked FES (so called functional electrical stimulation) of anal sphincter muscle which is insufficient for holding messy fecal soiling.