Opening Up Access to L-Sugars through a Synergy of Experiment and Theory

该项目旨在通过开发第一条合成L糖的广泛路线来解决碳水化合物科学中的一个主要瓶颈。L-糖是许多具有生物和商业意义的分子的关键成分，但由于大多数L-糖价格昂贵或难以制造，人们对其功能作用的了解受到阻碍。该项目希望通过合成化学和理论化学的创新结合，开发出快速合成L糖的路线。预期的结果包括显著提高获取L糖基生物分子纯样本的能力，以研究它们的生物功能。预计疫苗、诊断和生物材料的开发将带来重大好处。

This project aims to address a major bottleneck in the science of carbohydrates by developing the first broad-scope synthetic routes to L-sugars. L-sugars are critical components of many biologically and commercially significant molecules, but knowledge of their functional roles is impeded by the fact that most L-sugars are expensive or difficult to make. This project expects to develop expeditious routes to L-sugars via an innovative combination of synthetic and theoretical chemistry. Expected outcomes include a markedly increased capacity to access pure samples of L-sugar-based biomolecules, as needed for studying their biological functions. Significant benefits in the development of vaccines, diagnostics and biomaterials are anticipated.