Assessment of pathopysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac failure by using myocardial metabolic and receptor imaging.

心脏病理生理诊断评价及疗效定量评价。1995年至1998年用心肌代谢和受体显像研究了心肌衰竭。本文从基础和临床两方面进行了以下研究。利用离体大鼠心脏灌注模型和放射自显影技术，阐明了^<123>I-BMIPP的代谢。^<31 b> P-MR谱也明确了休克心肌的葡萄糖摄取，证实是由葡萄糖转运体易位引起的。对^<99M> tc -硝基咪唑的示踪动力学进行了澄清。这些示踪剂应用于DCM仓鼠（bio4_ < β >6）等动物模型。放射自显像证实代谢和受体变化先于血流和功能变化。临床研究使用SPECT和PET^<123 b> I-BMiPP心肌SPECT可评价肥厚性心肌病（HCMz）的严重程度和辅酶q10对扩张型心肌病（DCM）的治疗效果。^<123>I-MIBG对β -受体阻滞剂对DCM的严重程度和治疗效果有帮助。此外，^<18 b> F-FDG心肌PET对HCM和DCM的病理生理诊断非常有用。这些发现对于心脏运输的指征是必要的。

Assessment of pathophysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac . failure has been investigated by using myocardial metabolic and receptor imaging from 1995 to 1998. The following researches were done from the basic and clinical points.1. basic research using isolated perfused rat heart and autoradiographyMetabolism of ^<123>I-BMIPP was clarified by isolated perfused rat heart model. Glucose uptake in stunned myocardium was also clarified by ^<31>P-MR spectroscopy and it was confirmed to be caused by the translocation of glucose transporter. Tracer kinetics of ^<99M>Tc-nitroimidazole was also clarified. These tracers were applied to animal models such as DCM hamster (Bio l4_<beta>6) etc. It was conformed that the metabolic and receptor changes were preceded before the flow and functional changes by autoradiography.2. clinical research using SPECT and PET^<123>I-BMiPP myocardial SPECT was useful for the assessment of severity of hypertrophic cardiomyopathy (HCMz) and therapeutic effect of Coenzyme Q1O in dilated cardiomyopathy (DCM). ^<123>I-MIBG was useful for the severity and therapeutic effect of BETA-blocker in DCM.Furthermore, ^<18>F-FDG myocardial PET was extremely useful for the pathophysiologic diagnosis of HCM and DCM.These findings should be necessary for the indication of heart transportation.