Relation between porphyrin-metabolic disorders and some internal factors in lead-exposed subjects

为了阐明铅诱发的卟啉代谢紊乱与一些内在因素的关系，我们首先研究了血浆中delta-氨基乙酰丙酸（ALA）、尿液中ALA和尿中比例卟啉（CP）等生物学参数在铅职业暴露的男女工人中的反应是否存在差异。生物样本（尿液和血液）取自约300名铅工人（160名男性和138名女性）。血铅浓度（平均<正负>SD）（男性55<正负>13杯子/dl；女性55<正负>14杯子/dl）表明两组职业铅暴露强度基本相等。另一方面，在这些领头工人中，血浆ALA浓度的升高以及尿液ALA和CP排泄的增加在女性中要比男性高得多。这一数据证实了人体暴露的生物学效应存在性别差异的发现。其次，我们测定了血液样本中的一些生物学参数，如铜、锌、维生素E、β -胡萝卜素和超氧化物歧化酶（SOD）活性。然而，我们没有发现这些参数与铅暴露工人卟啉代谢紊乱程度之间的显著关系。

To elucidate the relationship between lead-induced porphyrin metabolic disorders and some internal factors, we first investigated whether the response of biological parameters such as plasma delta-aminolevulinic acid (ALA), urinary ALA,and urinary coproporphyrin (CP) differs between male and female workers occupationally exposed to lead.The biological samples (urine and blood) were obtained from about 300 lead workers (160 males and 138 females). The concentrations (mean<plus-minus>SD) of blood lead (males : 55<plus-minus>13 mug/dl ; females : 55<plus-minus>14mug/dl) indicated that the intensity of occupational exposure to lead was almost equal in the two groups. On the other hand, the elevation of plasma ALA concentration and the increased urine ALA and CP excretions among these lead workers were much higher in females than in males. This data confirms the finding of a sex difference in the biological effect of human expSecondly, we determined some biological parameters such as copper, zinc, vitamin E,beta-carotene, and superoxide dismutase (SOD) activity in the blood samples. However, we could not find significant relations between these parameters and the degree of porphyrin metabolic disorders in lead-exposed workers.