Immunological analysis of osteopenea during pregnancy and puerperium

在怀孕期间，高雌激素水平曾被认为可以保护母体的骨和骨吸收被禁止。产后低雌激素、高催乳素被认为可引起骨吸收。然而，我们对骨代谢标志物和骨矿物质密度的分析显示，妊娠期间骨吸收增加，产褥期骨形成增加。在非妊娠期，外周血单个核细胞释放的细胞因子IL-1、IL-6和TNF-α激活破骨细胞功能并诱导骨吸收。我们分析了外周血单个核细胞产生的细胞因子，发现在妊娠期高雌激素水平下，产生大量的细胞因子。这与当今骨代谢中的雌激素学说是矛盾的。我们必须阐明这种矛盾的免疫现象在怀孕期间。

During pregnancy, high estrogen levels had thought to protect the maternal bone and bone resorption to be prohibited. and after delivery, low estrogen and high prolactin had thought to induce bone resorption. Our analysis of bone metabolic marker and bone mineral density, however, disclosed that bone resorption is increased during pregnancy and in the puerperium bone formation is increased. During no pregnancy, cytokines released by peripheral mononuclear cells, IL-1, IL-6 and TNF-alpha, activate the osteoclast function and induce the bone resorption. We analyzed the production of cytokines from the peripheral mononuclear cells and found that, in high estrogen levels in pregnancy, much amount of cytokines were produced. This is paradoxical phenomenon compared with nowadays estrogen dogma in bone metabolism. We must elucidate this paradoxical immune phenomenon during pregnancy.