Studies on the risks assessment and the management of the development of insecticide resistance

(1)杀虫剂抗药性发展风险评估研究：不同类型杀虫剂对各种杀虫剂的实验室选择会导致对所选杀虫剂产生抗药性。不同种类和选用的杀虫剂在抗药性发展速度和抗药性稳定性上存在较大差异。在小菜蛾中，杀虫剂敏感品系和抗性品系对性信息素的敏感性存在较大差异。(2)抗药性发展的管理研究。(A)研究杀虫剂抗药性形成的生理、生化和分子机制。根据乙酰胆碱酯酶对杀虫剂的敏感性，发现了一组具有负相关交叉抗性的杀虫剂组合。随着抗药性发展的机制，在不同的抗药性案例中，靶点的降解增加和敏感性降低被阐明。(B)根据上述结果，开发和建立了各种简单的抗药性监测方法。基于我们研究小组取得的这些结果，有必要进一步研究建立害虫综合管理。

(1) Studies of the risk assessment on the development of insecticide resistance : Laboratory selection of various insecticides by various types o insecticides lead to the development of resistance to the selected insecticides. There were big differences in the speed of the development of insecticide resistance and the stability of insecticide resistance among insect species and kinds of selected insecticides. In the diamondback moth, a big difference was found in the sensitivity to sex pheromone between insecticide susceptible and resistant strains. (2) Studies on the management of the development of insecticide resistance. (a) Studies on the physiological, biochemical and molecular mechanisms of the development of insecticide resistance. Based on the sensitivity of AChE to insecticides, a combination of insecticides which show negatively correlated cross-resistance was found. As mechanisms of the development of insecticide resistance, increased degradation and decreased sensitivity of target site were clarified in various cases of insecticide resistance. (b) Based on the above results, various simple monitoring methods for insecticide resistance were developed and established. Based on these results obtained by our research team, further studies to establish integrated pest management are necessary.