Basic Study of sound-dynamic Therapy for Atherosclerotic Cerebrovascular Disease.

近年来随着超声技术的进步，声化学诱导细胞损伤（声动力疗法）在医学的各个领域得到了广泛的研究，尤其是在治疗癌症方面。在这个时候，这些研究已经证明了声敏材料（声敏剂）的实用性，如强力霉素（DC），血卟啉和柔柔比星（DR）。这些结果表明，激活DC的声化学诱导细胞损伤可能是通过声致发光介导的，而DR可能是通过单线态氧介导的。超声激发积聚在动脉粥样硬化斑块中的DC，提示声动力治疗动脉粥样硬化性脑血管病的能力。另一方面，作为超声的物理效应，我们研究了水下冲击波与气泡相互作用产生的液体射流在脑栓塞急性纤溶治疗中的应用效果。模拟研究使用明胶作为栓子模型和聚四氟乙烯管作为模拟血管壁进行。利用高速摄像机对液体射流的穿透深度进行了可视化。提示气泡与水下冲击波相互作用诱导的液体射流冲击作为脑闭塞性疾病的一种新的血运重建方式具有一定的潜力。

Concomitantly with the progress of ultrasound technology in recent years, sonochemically induced cell damage (Sound-dynamic therapy) syudied various medical field, especially to treatment for cancer. In this time, these studies have demonstrated utility of sonosensitive materials (sonosensitizer) such as doxycycline (DC), hematoporphyrin and daunorubicine (DR). These results suggests that sonochemically induced cell damage by activated DC is probably mediated via sonoluminescence and by DR is probably mediated via singlet oxygen. Furthermore DC to accumulated in atheromatous plaque was excited by insonation, indicates the capability of Sound-dynamic therapy for atherosclerotic cerebrovascular disease.On the other hand, as the physical effect of ultrasound, we studied the efficacy of a liquid jet generated by the interaction of an underwater shock wave with air bubble to apply to acute fibrinolysis for cerebral embolism. Simulation studies using gelatin as embolus model and a teflon tube as a mimic vascular wall were performed. The penetration depth attained of the liquid jet was visualized by means of a high speed camera. It was suggested that the liquid jet impact induced by interaction between bubble and underwater shock waves had some potentiality as a new modality of revascularization for cerebral occlusive diseases.