Biological effects of whole body exposure to static magnetic fields.

本研究的目的是探讨静磁场的生物效应。本实验研究了4.7T静磁场对小鼠摄食量、饮水量及血清生化指标的影响。暴露48 h后，食物和水摄入量及体重均显著下降。4.7T SMF暴露后24 h，小鼠肝脏苯胺脱氢酶活性显著升高，而3.0T SMF暴露后24 h，小鼠肝脏苯胺脱氢酶活性无显著变化。4）4.7T SMF对小鼠肝脏自由基的产生有影响。四氯化碳（CCl_4）也能引起组织中的自由基。然后，4.7T SMF对小鼠肝组织中金属硫蛋白有诱导作用; 4.7T SMF对哺乳动物细胞微核的诱导作用增强; 4.7T SMF对小鼠肝组织中金属硫蛋白有诱导作用; 4.7T SMF对哺乳动物细胞微核的诱导作用增强。用低频磁场和SMF对果蝇进行了观察。

The aim of this studies is to investigate a biological effects of static magnetic fields. The following results were obtained for 2 years investigation.1) The effects of 4.7 tesla (T) static magnetic fields (SMF) on food and water intake and some serum biochemical parameters in mice were examined. Food and water intake and body weight decreased statistically after 48 h of exposure. The blood urine nitrogen and blood glucose levels increased significantly after 48h of exposure.2) Enzyme activity of aniline dehydrogenase in mouse liver increased significantly 24h after exposure to 4.7T SMF,but not 3.0T SMF.3) No significant effect of enzyme activity in mouse liver treated with 7,12- dimethylbenzanthracene was observed after exposure to SMF.4) 4.7T SMF influences the production of free radicals in mouse liver. It is known that carbontetrachloride (CCl_4) also induces the free radical in tissues. Then, combination exposure of CCl_4 and SMF enhances the production of free radicals in liver of mice than exposure of them separately.5) 4.7T SMF also induces metallothionein in liver of mice.6) Induction of micronuclei induced by mitomycin C in mammalian cultured cells was increased 48h exposure to 4.7T SMF.7) Mutagenic effects of spot-test using Drosophila melanogaster were observed by SMF and low frequency magnetic fields.