Obstructed Migration of Trigeminal Motoneurons and Trigeminal

Reeler(基因符号，rl)是发生在小鼠体内的一种常染色体隐性突变，其特征是神经元在中枢神经系统中的位置异常。然而，在这个突变体中，周围神经系统的细胞结构是正常的，这意味着卷轴遗传位点不会影响周围系统中神经元的迁移。中脑三叉神经核(Me5)神经元的独特之处在于，它们像周围神经系统中的其他神经元一样起源于神经脊，但次级进入中枢神经系统。我们通过将辣根过氧化物酶或快速蓝注射到正常和卷曲的小鼠的颞肌中来标记Me5神经元，以确定这些神经元的迁移是否受到卷曲的遗传位点的影响。与正常小鼠相比，卷曲小鼠标记的Me5神经元分布更广，这表明卷曲遗传位点影响起源于神经脊的神经元的迁移，然后迁移到中枢神经系统。

Reeler (gene symbol, rl) is an autosomal recessive mutation occurring in mice and characterized by the abnormal positioning of neurons in the central nervous system. In this mutant, however, the cytoarchitecture of the peripheral nervous system is normal, implying that the reeler genetic locus does not affect migration of neurons in the periperal system. Mesencephalic trigeminal nucleus (Me5) neurons are unique in that they are derived from the neural crest like other neurons in the peripheral nervous system, but enter secondarily the central nervous system. We labeled Me5 neurons by injecting horseradish peroxidase or Fast Blue into the temporal muscle of normal and reeler mice to determine whether the migration of these neurons is affected by the reeler genetic locus. Labeled Me5 neurons of the reeler mouse were more widely scattered in comparison with their normal counterparts, suggesting that the reeler genetic locus affects migration of neurons which originate in the neural crest and then migrate into the central nervous system.