Sointigraphic Detection of Overexpressed c-erbB-2 Protooncogene Products for Breast Cancer by ^<125>I-labelled Anti-c-erbB-2 Monoclonal Antibody

在这项研究中，利用放射性标记的SV2-61伽马进行放射免疫检测，以评估c-erbB-2原癌基因产物的过度表达，使用几种裸鼠肿瘤模型。免疫核素图显示^&lt；125&gt；I标记的抗c-erbB-2MoAbs在裸鼠实验肿瘤模型中定位乳腺癌的能力。因此，该抗体与乳腺来源细胞上的膜抗原的独特结合使该抗体成为乳腺癌成像和放射免疫治疗的潜在条件。

In this investigation, radioimmunodetection with the potential of radiolabelled SV2-61 gamma was performed for evaluating the overexpression of c-erbB-2 protooncogene products, using several tumor models in nude mice.The immunoscintigram demonstrated the ability of ^<125>I-labelled anti-c-erbB-2MoAbs to localize breast cancer in an experimental tumor model in nude mice. The unique binding to a membrance atigen on cells of breast origin therefore makes the antibody a potential condidate for imaging and radioimmunotherapy of breast cancer.