THE EFFECT OF OVERPRODUCTION OF ENDOLYMPH ON THE INNER EAR FUNCTION

为了研究内淋巴过度产生对内耳功能的影响，将人工内淋巴注射到动物的中阶，观察其听功能和前庭功能。结果如下：1)电灼内淋巴囊可诱发内淋巴积水。烧灼后2个月出现中、重度积水。在这些动物中，正和负的耳蜗内电位已经降低。耳蜗管内注入人工内淋巴对这些电位无明显影响，但正常动物的负内淋巴电位有所下降。2)实验性积水动物的复合动作电位和耳蜗微音学也明显降低。这些电位在人工内淋巴注射前后无明显变化。在当前的Se…中无法检测到延迟的CM更多的实验。3)烧灼后2周可检测到瞬间诱发耳声发射(TEOA)，2个月后消失。因此，没有研究人工内淋巴注射对TEOAE的影响。可以记录到失真产物耳声发射(DPOAE)，但由于其不稳定性，无法检测人工内淋巴注射对DPOAE的影响。4)人工内淋巴注入耳蜗管对正常动物和实验性积水动物的前庭神经自发放电均无影响。5)耳蜗管内注入人工内淋巴后，无论是正常动物还是实验性积水动物，鼓阶K~+活性均无明显变化，以往的研究认为，耳蜗术后中层K~(++)浓度过高是由于内淋巴通过扩大的Reissner膜渗漏所致。然而，目前的结果并不支持这一假设。较少

In order to study the effect of an overproduction of the endolymph on the inner ear function, artificial endolymph was injected into the scala media in animals with the experimentally-induced endolymphatic hydrops, and the auditory and vestibular functions were examined. The results were as follows : 1) Endolymphatic hydrops was induced by electro-cauterization of the endolymphatic sac. Moderate or severe hydrops developed 2 months after the cauterization. In these animals, the positive and negative endocochlear potentials had already decreased. Artificial endolymph injection into the cochlear duct produced no significant alteration in these potentials, although the negative endolymphatic potential decreased in normal animals. 2) The compound action potentials and cochlear microphonics also decreased in animals with experimentally induced hydrops. These potentials showed no change before and after the artificial endolymph injection. The delayd CM could not be detected in the present se … More ries of experiments. 3) Transient evoked otoacoustic emission (TEOA) was detected 2 weeks after the cauterization of the sac, but disappeared after 2 months. Thus, the effect of artificial endolymph injection to TEOAE was not investigated. Distortion product otoacoustic emission (DPOAE) could be recorded, but we could not examine the influence of artificial endolymph injection on DPOAE because of its instability. 4) Artificial endolymph injection into the cochlear duct produced no alteration in spontaneous discharge of the vestibular nerve either in normal animals or in animals with experimentally induced hydrops. 5) artificial endolymph injection into the cochlear duct produced no alteration in K^+ activity in the scala tympani either in normal animals or in animals with experimentally induced hydrops.In the previous studies, cochlear and vestibular dysfunction seemed to be attributed to high concentration of K ^+ in the scala media due to the leakage of endolymph via extended Reissner's membrane. However, the present results did not favor this hypothesis. Less