The Pathogenic effect of free radical in the inner ear and its cyrative methods

我们考察了在某些病理条件下内耳是否处于自由基诱导的情况下，得到了以下结果：氨基糖苷衍生物可以剂量依赖性地诱导豚鼠耳蜗外毛细胞细胞膜上的自由基，并且这些自由基在局部发生变异。耳蜗侧壁的血流受一氧化氮的调节，一氧化氮产生于耳蜗毛细血管或螺旋血管内皮。巨噬细胞在鼓膜上被识别。这些巨噬细胞有可能通过产生自由基来保护内耳对抗病原体。生物反应修饰剂（Biological response modifier， BRM）能够诱导内耳巨噬细胞的早期出现，这意味着内耳可以通过人工方式成为感染过程的受影响器官。

We investigated whether the inner ear is under the circumstance where free radical is induced under some pathological conditions, and we got the following results.#1.Aminiglycoside derivatives can dose-dependently induce free radical at the cell membrane of outer hair cells in the guinea pig cochlea and these free raidcals are locally dismutated.#2.The blood flow of the cochlear lateral wal is regulated by nitric oxide which is produced in the endothlium of strial capillary or spiral vessel.#3.The residential macrophages were recognized on the membrane of the scala tympani. These macrophages have a possibility to protcet the inner ear by producign free radiocals against pathogens.#4.Biological response modifier (BRM) could indece the early emergence of macrophages in the inner ear which means that the inner ear can be an affected organ by artificial manner to infection process.