Role of Essential Trace Metals in brain

用<65><54>高分辨放射自显影技术对静脉注射ZnCl_2或MnC_2的大鼠脑进行了观察。注射<65>后<54>6d ~ 42 d，~（54）Zn和~（54）Mn在各脑区的分布逐渐减少<65>，~（54）Zn在15 d ~ 60 d。锌在每个研究区域的生物半衰期在16-43天的范围内，杏仁核中观察到的最长。观察到长生物半衰期的区域与先前报道的具有高密度含锌中子末端的区域一致。为了研究锌在大鼠嗅束中的迁移性，<65>用放射自显影法分析了嗅球或杏仁核注射锌后的脑内分布。嗅<65>球内注射微量锌后24 h<65>， ...更多信息 分布于同侧梨状皮质、杏仁核和前连合。此外，在嗅球内注射较高水平的^ Zn的情况下<65>，^<65>Zn除了分布在上述区域外，还分布在同侧的内嗅皮层中。杏仁<65>核注射~（13）Zn后24 h，<65>~（13）Zn分布于同侧梨状皮质和内嗅皮质。这些结果表明，锌是神经元内运输沿着嗅束。锌从次级嗅神经元终末释放后，可被梨状神经元摄取，并转运到内嗅区。<65>将锌注入大鼠纹状体或黑质，观察脑内锌的迁移情况。纹状体内注射时，~<65>（13）Zn主要分布于内侧前脑束和黑质。在黑质内注射的情况下，^<65>Zn密集分布在MFB中，也在纹状体和苍白球中。在一侧MFB注射秋水仙碱后<65>，纹状体注射锌后，同侧黑质内锌的分布显著低于对侧<65>。这些结果表明，存在的轴突运输锌的途径中的g-氨基丁酸（GABA）能纹状体黑质纤维。此外，两次<65>注射后1天的^ Zn分布数据表明其分布区域为GABA能系统。少

The brains of rats injected intravenously with ^<65>ZnCl_2 or ^<54>MnC_2 were subjected to high-resolution autoradiography. The distribution of ^<65>Zn and ^<54>Mn in each brain region gradually decreased from 6 days to 42 days for ^<65>Zn and form 15 days to 60 days for 54 Mn after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days ; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuton terminals reported previously. The biological half-lives of Mn in each region determined were 51-74 days ; the longest were those in the hypothalamic nuclei and thalamus.To study zinc (Zn) mobility in the rat olfactory tract, brain distribution of ^<65>Zn after injection into the olfactory bulb or amygdaloid nuclei was analyzed by autoradiography. Twenty-four h after ^<65>Zn injection into the olfactory bulb, ^<65>Zn was … More distributed in the ipsilateral piriform cortex, amygdaloid nuclei and the anterior commissure. Moreover, in the case of injection of a higher level of ^<65>Zn into the olfactory bulb, ^<65>Zn was distributed in the ipsilateral entorhinal cortex in addition to the above regions. Twenty-four h after ^<65>Zn injecjtion into the amygdaloid nuclei, ^<65>Zn was distributed in the ipsilateral piriform and entorhinal cortex. These results suggest that Zn is intraneuronally transported along the olfactory tract. Zn may be taken up by the piriform neurons after release from the secondary olfactory neuron terminals and transported to the entorhinal area.^<65>Zn was injected into the striatum or substantia nigra of rats to see the mobility of intracerebral Zn. In the case of intrastriatal injection, ^<65>Zn was densely distributed in the medial forebrain bundle (MFB) and substantia nigra. In the case of intranigral injection, ^<65>Zn was densely distributed in the MFB and also in the striatum and globus pallidus. On unilateral colchicine injection into the MFB,^<65>Zn distribution in the ipsilateral substantia nigra decreased significantly compared to that of the contralateral one after ^<65>Zn injection into the striatum. These results suggest the presence of axonal transport of Zn in pathway of g-amino butyric acid (GABA)-ergic striato-nigra fibers. Moreover, the ^<65>Zn distribution data 1 day after both injections indicated that its distributed regions were those with the GABAergic systems. Less