Elucidating the molecular basis of plant potyvirus resistance

植物病毒是造成农作物损失的主要原因，遗传抗性是目前控制病毒传播的最有效手段。该项目在分子和结构水平上研究在感染期间劫持植物病毒的宿主因素，特别是这些因素中赋予抗药性的突变。我们的目标是进一步阐明植物病毒克服这些寄主因子介导的抗性的机制。对植物病毒及其寄主之间的分子相互作用的详细了解将有助于设计出新的、强大的和更有效的抗性形式。因此，这项工作对澳大利亚的农业生产力具有经济和环境影响。

Plant viruses are responsible for a large proportion of crop losses, and genetic resistance is currently the most effective means to control viral spread. This project investigates, on a molecular and structural level, host factors that plant viruses hijack during infection, and in particular, the mutations in these factors that confer resistance. We further aim to elucidate the mechanisms by which plant viruses overcome resistance mediated by these host factors. A detailed understanding of the molecular interactions between plant viruses and their host will enable new, robust and more effective forms of resistance to be engineered. This work therefore has economic and environmental implications for agricultural productivity in Australia.