Diet, genetic factor and cancer in Japanese Brazilian

（1）横断面研究我们从圣保罗随机抽样的166名年龄在47至75岁的日裔巴西人中获得了3天的饮食记录，并将这些数据与日本的5个日裔人群进行了比较。日裔巴西人消耗更多的糖和汗水，豆类，水果，鸡肉和红肉，而较少的大豆制品，蔬菜和泡菜。我们尝试在尸检病例的肝、肾和结肠组织以及结肠癌患者的结肠组织中检测杂环胺-DNA加合物，例如dG-C8-MeIQx和dG-C8-PhIP，然而所有样品均低于我们的测量方法的检测限。（2）胃癌的病例对照研究：病例组为101例日裔巴西人和245例非日裔巴西人胃癌患者，对照组分别为202例和245例非癌患者。在日本人中，牛肉消费与胃癌风险增加有关，而在非日本人中没有发现这种关联。蔬菜摄入量与非日本人的风险降低有关，而日本人则没有。这些饮食危险因素的不一致性可能是由于两组之间这些食物的摄入水平不同造成的。CYPIE 1的RsaI多态性分布在两组病例和对照之间相似，但在日本人和非日本人之间有显著差异。

(1)Cross-sectional studyWe obtained a 3 day dietary record form 166 randomly sampled Japanese Brazilians aged 47 to 75 years in Sao Paulo and compared these data with five Japanese populations in Japan. Japanese Brazilians consumed more sugar and sweats, beans, fruits, chickes and red meats, while less soybean products, vegetables and pickled vegetables. We tried to detect heterocyclic amine-DNA adducts such as dG-C8-MeIQx and dG-C8-PhIP in liver, kidney and colon tissues from autopsy cases and in colon tissues from colon cancer patients, however all samples were less than our detection limit of measurement method.(2)Case-control study of stomach cancerCases were 101 Japanese Brazilians and 245 non-Japanese Brazilian with stomach cancer and controls were 202 and 245 patients without cancer, respectively. Beef consumption was associated with increased risk of stomach cancer in Japanese, while this association was not found in non-Japanese. Vegetable intake was associated with reduced risk in non-Japanese, while not in Japanese. These discordance of dietary risk factors may be cause by different intake level of these foods between two groups. The distributions of RsaI polymorphism of CYPIIE1 were similar between cases and controls in both groups, however these were significantly different between Japanese and non-Japanese.