Molecular Mechanisms of Genomic Instability and DNA Repair

我们从分子水平到生物体水平研究了各种DNA修复机制及其缺陷的后果。我们将我们的研究分为以下三个主题。切除修复的机制及其缺陷的分子后果。同源重组和重组修复的机制。为了有效地支持这一研究项目，咨询委员会开展了以下活动：1.突变的分子机制。我们在财政上支持了几个研究小组，当我们发现在这些研究领域的进展方面支持他们更好。我们出版了研究论坛，并与所有成员举行了会议，以促进信息交流。我们为相关的两个讲习班提供了财政支持，这两个讲习班每年都举行。一个是“基因重组及其调控研讨会”，另一个是“DNA修复和突变研讨会”。我们每年召开两次咨询委员会，以评估研究小组的结果，并获得对未来研究方向的建议。我们支持研究人员参加国际会议。我们还邀请了外国研究人员来日本，以方便信息交流。我们在最后一年出版了一本书，介绍了该项目所有成员的研究活动，包括相关出版物的清单及其代表性论文的副本。

We have studied various DNA repair mechanisms and the consequence of their defects from molecular to organism level. We categorized our studies into the following three subjects.1. Mechanisms of excision repair and molecular consequence of their defects.2. Mechanisms of homologous recombination and recombination repair.3. Molecular mechanisms of mutagenesis.In order to support this research project effectively, the advisory committee has conducted the following activities.1. We have financially supported a couple of research groups, when we found that it is better to support them with respect to the progress bf those research areas.2. We have published research forums and had meetings with all the members in order to facilitate exchange of information.3. We have financially supported related two workshops, which have been held annually. One is "Workshop on Genetic Recombination and Its Regulation", and the other is "Workshop on DNA Repair and Mutagenesis".4. We have held advisory committee twice per year in order to evaluate the outcomes of the research groups and to obtain suggestions for future research direction.5. We have supported researchers to attend international meetings. We have also invited foreign researchers to Japan in order to facilitate the exchange of information.6. We have published at the final year a book, which describes research activities of all the members of this project including the list of related publications and copies of their representative paper.