A follow up study of the health effects caused by methyl mercury exposure in a population living the methyl mercury polluted area.

MD患者通常具有神经学体征，例如共济失调、言语障碍和视野收缩以及感觉障碍。但并不是所有的MD患者都有典型的甲基汞中毒，慢性MD患者尤其表现出亚临床特征。有几项研究调查了主观主诉和比对照人群更低的ADL，并且神经系统体征、主观主诉和ADL受到衰老和伴随衰老的并发症的影响。关于甲基汞和甲基汞污染的一些医学和社会问题仍在辩论中，其中包括甲基汞中毒的长期影响以及对甲基汞污染地区总人口的影响。尽管由于大约40年过去了，甲基汞中毒可能受到各种因素的影响，因此很难澄清这些问题，但我们应该尝试证明不仅是MD患者的健康状况，而且生活在 ...更多信息 污染区。本研究的目的是记录甲基汞污染区总体人群的主观抱怨和日常生活能力障碍，分析其结构，并探讨这些健康影响与甲基汞暴露之间的关系。渔村的许多投诉和残疾的患病率高于其他地区。通过因子分析，得到4个因子，总的累积特征值百分比为47.0%。因子1的特征值百分比最高（23.1%），包括蹒跚、眩晕和头晕、心脏不适、僵硬和震颤。因子3为关节病、关节痛、耳鸣听力障碍、小便不适。因子4是肌肉萎缩和虚弱。渔村在各因子上的得分均高于其他地区。因子分与红细胞汞和鱼类消费量的相关分析结果表明，除第一、第三因子分与男性鱼类消费量关系不大外，其他因子分与鱼类消费量和红细胞汞均存在显著相关关系。因子分析显示，残疾由两个因子构成：肢体残疾因子和沟通障碍因子。污染区居民各因子得分均高于对照区。多元回归分析的结果表明，老龄化、水患证和居住地差异对残疾有影响。这些结果表明，汞暴露、老龄化和与居住地有关的因素使甲基汞污染区居民的日常生活能力残疾程度增加。少

MD patients typically have neurological signs such as ataxia, speech impairment, and constriction of visual fields, and sensory disturbance. But not every MD patients have typical MeHg poisoning, and chronic MD patients in particular show subclinical features. There are a few studies investigating subjective complaints and lower ADL than a control population and that neurological signs, subjective complaints, and ADL were influenced by aging and complications accompanying aging. Some of the medical and social issues which are still being debated with regard to MD and MeHg pollution are the long-term influence of MeHg poisoning and the impact on the overall population in the methyl mercury polluted area. Althoughit is likely to be very difficult to clarify these issues because about four decades have passed and the MeHg poisoning has possibly been modified by various factors, we should attempt to demonstrate the health status not only of MD patients but also other inhabitants living in … More the polluted area. The aim of the present study was to document the subjective complaints and the disability of daily living, and to analyze their structure in an overall population in the MeHg polluted area and to investigate the relationship between these health effect and methyl mercury exposure. Fishing villages have a higher prevalence of many complaints and disability than other area. By the factor analysis, four factors were obtained and the total cumulative eigenvalue percentage was 47.0%. Factor 1, whose eigenvalue % was the highest (23.1%) of all, consisted of staggering, vertigo and dizziness, heart-complaint, stiffness, and tremor. Factor 3 was arthrederma, arthralgia, tinnitus and difficulty of hearing, and urinary-complaints. Factor 4 was muscular atrophy and weakness. Fishing villages had higher scores in all factors than others. The results of the correlation with factor scores and RBC Hg or fish consumption showed that there was obviously relationship between factor scores and fish consumption or RBC Hg expect for a little relationships between the first and third factor scores and fish consumption in males. A factor analysis also documented that the disability was composed of two factors : physical disability factor and communication disability factor. The factors score are higher of the inhabitants in polluted area than the control. As a result of multiple regression analysis, the disability is influenced by aging, the certification of Minamata disease and the difference of residential areas : These results suggests that the disability of daily living in a population living in the methyl mercury polluted area has been advanced by mercury exposure, aging, and something related with residential areas. Less